Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959792972> ?p ?o ?g. }
- W2959792972 abstract "Targeting the VEGF signaling required for neovascularization by vaccination with chimeric capsids of oncolytic viruses may boost therapy for solid tumors. VEGF-blocking peptides (VEbp) engineered in the capsid 3-fold axis endowed the infectious parvovirus MVM with the ability to induce α-VEGF antibodies without adjuvant and to evade neutralization by MVM-specific antibodies. However, these properties may be compromised by structural restraints that the capsid imposes on the peptide configuration and by misassembly caused by the heterologous peptides. Significantly, chimeric MVM-VEbp resolved the structural restrictions by selecting mutations within the engineered peptides that restored efficient capsid assembly. These data show the promise of antineovascularization vaccines using chimeric VEbp-icosahedral capsids of oncolytic viruses but also raise safety concerns regarding the genetic stability of manipulated infectious parvoviruses in cancer and gene therapies." @default.
- W2959792972 created "2019-07-23" @default.
- W2959792972 creator A5006510723 @default.
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- W2959792972 creator A5091282555 @default.
- W2959792972 date "2019-10-01" @default.
- W2959792972 modified "2023-09-26" @default.
- W2959792972 title "Antiangiogenic Vascular Endothelial Growth Factor-Blocking Peptides Displayed on the Capsid of an Infectious Oncolytic Parvovirus: Assembly and Immune Interactions" @default.
- W2959792972 cites W1480402597 @default.
- W2959792972 cites W1543597283 @default.
- W2959792972 cites W1556659925 @default.
- W2959792972 cites W1598111769 @default.
- W2959792972 cites W1752063116 @default.
- W2959792972 cites W1902344475 @default.
- W2959792972 cites W1921973844 @default.
- W2959792972 cites W1964959966 @default.
- W2959792972 cites W1965250103 @default.
- W2959792972 cites W1965786463 @default.
- W2959792972 cites W1966215542 @default.
- W2959792972 cites W1967682207 @default.
- W2959792972 cites W1971145302 @default.
- W2959792972 cites W1972168467 @default.
- W2959792972 cites W1981950767 @default.
- W2959792972 cites W1985354573 @default.
- W2959792972 cites W1987393676 @default.
- W2959792972 cites W1991447763 @default.
- W2959792972 cites W1991751622 @default.
- W2959792972 cites W1992112921 @default.
- W2959792972 cites W2003240567 @default.
- W2959792972 cites W2003942184 @default.
- W2959792972 cites W2004300505 @default.
- W2959792972 cites W2011849510 @default.
- W2959792972 cites W2028262440 @default.
- W2959792972 cites W2029613356 @default.
- W2959792972 cites W2033689077 @default.
- W2959792972 cites W2035411770 @default.
- W2959792972 cites W2041435284 @default.
- W2959792972 cites W2042349690 @default.
- W2959792972 cites W2049853614 @default.
- W2959792972 cites W2050916809 @default.
- W2959792972 cites W2052248615 @default.
- W2959792972 cites W2053474695 @default.
- W2959792972 cites W2053820810 @default.
- W2959792972 cites W2055981634 @default.
- W2959792972 cites W2057347572 @default.
- W2959792972 cites W2057943246 @default.
- W2959792972 cites W2059123072 @default.
- W2959792972 cites W2059193290 @default.
- W2959792972 cites W2060912418 @default.
- W2959792972 cites W2061013034 @default.
- W2959792972 cites W2064788762 @default.
- W2959792972 cites W2070119976 @default.
- W2959792972 cites W2077695260 @default.
- W2959792972 cites W2078023230 @default.
- W2959792972 cites W2078687083 @default.
- W2959792972 cites W2079150475 @default.
- W2959792972 cites W2079990421 @default.
- W2959792972 cites W2082890587 @default.
- W2959792972 cites W2083375727 @default.
- W2959792972 cites W2088212973 @default.
- W2959792972 cites W2092768795 @default.
- W2959792972 cites W2098434403 @default.
- W2959792972 cites W2114098415 @default.
- W2959792972 cites W2116947227 @default.
- W2959792972 cites W2118812359 @default.
- W2959792972 cites W2124228985 @default.
- W2959792972 cites W2125272498 @default.
- W2959792972 cites W2128703190 @default.
- W2959792972 cites W2128753750 @default.
- W2959792972 cites W2140264123 @default.
- W2959792972 cites W2141710903 @default.
- W2959792972 cites W2142785166 @default.
- W2959792972 cites W2145835533 @default.
- W2959792972 cites W2146953551 @default.
- W2959792972 cites W2156202423 @default.
- W2959792972 cites W2156894768 @default.
- W2959792972 cites W2157314889 @default.
- W2959792972 cites W2159725525 @default.
- W2959792972 cites W2164811737 @default.
- W2959792972 cites W2166681948 @default.
- W2959792972 cites W2167590237 @default.
- W2959792972 cites W2167776440 @default.
- W2959792972 cites W2168650845 @default.
- W2959792972 cites W2170679315 @default.
- W2959792972 cites W2171084404 @default.
- W2959792972 cites W2171618820 @default.
- W2959792972 cites W2175576464 @default.
- W2959792972 cites W2233607944 @default.
- W2959792972 cites W2293809486 @default.