FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959904898> ?p ?o ?g. }

• W2959904898 endingPage "4959" @default.
• W2959904898 startingPage "4949" @default.
• W2959904898 abstract "Cationic anticancer peptides, which can induce tumor cell immunogenic death and further promote systemic tumor-specific immune responses, have offered a promising solution to relieve the tumor immunosuppressive microenvironment. However, peptide drugs are easily degraded and lack of targeting ability when administered systemically, leading to limitations in their applications. Herein, we report a pH and thermal dual-sensitive bovine lactoferricin-loaded (one of the most widely studied cationic anticancer peptides) nanoparticles, which simultaneously exhibited antitumor and immune cell activated effects when applied with microwave thermotherapy, an auxiliary method of immunotherapy. The bovine lactoferricin could be delivered to the tumor site by nanoparticles, be immediately released from nanoparticles in the acidic environment of lysosomes and the thermal condition caused by microwave radiation, and ultimately induce tumor apoptosis with the release of damage-associated molecular patterns (DAMPs). It is worth noting that the strategy of bovine lactoferricin-loaded nanoparticles intravenous injection combined with local microwave thermotherapy not only showed excellent efficacy in relieving tumor growth but also resulted in strong antitumor immunities, which was due to the released bovine lactoferricin under stimulating conditions, and the pool of tumor-associated antigens generated by tumor destruction. In conclusion, this work presents a strategy for tumor treatment based on dual-sensitive bovine lactoferricin-loaded nanoparticles combined with microwave thermotherapy, which may provide a solution for cationic anticancer peptides delivery and improving antitumor immune responses." @default.
• W2959904898 created "2019-07-23" @default.
• W2959904898 creator A5003986323 @default.
• W2959904898 creator A5010773627 @default.
• W2959904898 creator A5022443764 @default.
• W2959904898 creator A5031267539 @default.
• W2959904898 creator A5034031051 @default.
• W2959904898 creator A5046313608 @default.
• W2959904898 creator A5046597133 @default.
• W2959904898 creator A5051691879 @default.
• W2959904898 creator A5061912479 @default.
• W2959904898 creator A5068902273 @default.
• W2959904898 creator A5078560718 @default.
• W2959904898 creator A5079486417 @default.
• W2959904898 creator A5086500887 @default.
• W2959904898 creator A5091324614 @default.
• W2959904898 creator A5091452344 @default.
• W2959904898 date "2019-07-09" @default.
• W2959904898 modified "2023-10-17" @default.
• W2959904898 title "pH and Thermal Dual-Sensitive Nanoparticle-Mediated Synergistic Antitumor Effect of Immunotherapy and Microwave Thermotherapy" @default.
• W2959904898 cites W1488772574 @default.
• W2959904898 cites W1551811315 @default.
• W2959904898 cites W1587050401 @default.
• W2959904898 cites W1918424817 @default.
• W2959904898 cites W1922412259 @default.
• W2959904898 cites W1942176190 @default.
• W2959904898 cites W1942897646 @default.
• W2959904898 cites W1965581922 @default.
• W2959904898 cites W1971372468 @default.
• W2959904898 cites W1979636792 @default.
• W2959904898 cites W1988479159 @default.
• W2959904898 cites W1993575340 @default.
• W2959904898 cites W1995079950 @default.
• W2959904898 cites W1996482425 @default.
• W2959904898 cites W1997357193 @default.
• W2959904898 cites W2002362946 @default.
• W2959904898 cites W2004426884 @default.
• W2959904898 cites W2011458181 @default.
• W2959904898 cites W2015095309 @default.
• W2959904898 cites W2016612145 @default.
• W2959904898 cites W2029701363 @default.
• W2959904898 cites W2042198735 @default.
• W2959904898 cites W2050417053 @default.
• W2959904898 cites W2054229004 @default.
• W2959904898 cites W2059657325 @default.
• W2959904898 cites W2067350492 @default.
• W2959904898 cites W2069119383 @default.
• W2959904898 cites W2071500774 @default.
• W2959904898 cites W2095554214 @default.
• W2959904898 cites W2099936767 @default.
• W2959904898 cites W2106801689 @default.
• W2959904898 cites W2107867323 @default.
• W2959904898 cites W2118748447 @default.
• W2959904898 cites W2120426523 @default.
• W2959904898 cites W2120630008 @default.
• W2959904898 cites W2132789515 @default.
• W2959904898 cites W2137520143 @default.
• W2959904898 cites W2140111836 @default.
• W2959904898 cites W2141285069 @default.
• W2959904898 cites W2142153200 @default.
• W2959904898 cites W2143398971 @default.
• W2959904898 cites W2165559987 @default.
• W2959904898 cites W2170369551 @default.
• W2959904898 cites W2174927103 @default.
• W2959904898 cites W2223615522 @default.
• W2959904898 cites W2301251359 @default.
• W2959904898 cites W2342423058 @default.
• W2959904898 cites W2409219020 @default.
• W2959904898 cites W2478138919 @default.
• W2959904898 cites W2566775074 @default.
• W2959904898 cites W2570618306 @default.
• W2959904898 cites W2626206073 @default.
• W2959904898 cites W2751683947 @default.
• W2959904898 cites W2754457053 @default.
• W2959904898 cites W2770355735 @default.
• W2959904898 cites W2770810616 @default.
• W2959904898 cites W2785532195 @default.
• W2959904898 cites W2789332370 @default.
• W2959904898 cites W2803372926 @default.
• W2959904898 cites W2809811258 @default.
• W2959904898 cites W2884447147 @default.
• W2959904898 cites W2897418729 @default.
• W2959904898 cites W409445623 @default.
• W2959904898 cites W4230350617 @default.
• W2959904898 cites W619024913 @default.
• W2959904898 doi "https://doi.org/10.1021/acs.nanolett.9b01061" @default.
• W2959904898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31286769" @default.
• W2959904898 hasPublicationYear "2019" @default.
• W2959904898 type Work @default.
• W2959904898 sameAs 2959904898 @default.
• W2959904898 citedByCount "37" @default.
• W2959904898 countsByYear W29599048982020 @default.
• W2959904898 countsByYear W29599048982021 @default.
• W2959904898 countsByYear W29599048982022 @default.
• W2959904898 countsByYear W29599048982023 @default.
• W2959904898 crossrefType "journal-article" @default.
• W2959904898 hasAuthorship W2959904898A5003986323 @default.
• W2959904898 hasAuthorship W2959904898A5010773627 @default.

• next