FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2960022472> ?p ?o ?g. }

• W2960022472 abstract "Triple negative breast cancer (TNBC) is a breast cancer subgroup characterized by a lack of hormone receptors’ expression and no HER2 overexpression. These molecular features both drastically reduce treatment options and confer poor prognosis. Platinum (Pt)-salts are being investigated as a new therapeutic strategy. The base excision repair (BER) pathway is important for resistance to Pt-based therapies. Overexpression of APE1, a pivotal enzyme of the BER pathway, as well as the expression of NPM1, a functional regulator of APE1, are associated with poor outcome and resistance to Pt-based therapies. We evaluated the role of NPM1, APE1 and altered NPM1/APE1 interaction in the response to Pt-salts treatment in different cell lines: APE1 knockout (KO) cells, NPM1 KO cells, cell line models having an altered APE1/NPM1 interaction and HCC70 and HCC1937 TNBC cell lines, having different levels of APE1/NPM1. We evaluated the TNBC cells response to new chemotherapeutic small molecules targeting the endonuclease activity of APE1 or the APE1/NPM1 interaction, in combination with Pt-salts treatments. Expression levels’ correlation between APE1 and NPM1 and their impact on prognosis was analyzed in a cohort of TNBC patients through immunohistochemistry. Bioinformatics analysis, using TCGA datasets, was performed to predict a molecular signature of cancers based on APE1 and NPM1 expression. APE1 and NPM1, and their interaction as well, protect from the cytotoxicity induced by Pt-salts treatment. HCC1937 cells, having higher levels of APE1/NPM1 proteins, are more resistant to Pt-salts treatment compared to the HCC70 cells. A sensitization effect by APE1 inhibitors to Pt-compounds was observed. The association of NPM1/APE1 with cancer gene signatures highlighted alterations concerning cell-cycle dependent proteins. APE1 and NPM1 protect cancer cells from Pt-compounds cytotoxicity, suggesting a possible improvement of the activity of Pt-based therapy for TNBC, using the NPM1 and APE1 proteins as secondary therapeutic targets. Based on positive or negative correlation with APE1 and NPM1 gene expression levels, we finally propose several TNBC gene signatures that should deserve further attention for their potential impact on TNBC precision medicine approaches." @default.
• W2960022472 created "2019-07-23" @default.
• W2960022472 creator A5008890940 @default.
• W2960022472 creator A5009976972 @default.
• W2960022472 creator A5020923936 @default.
• W2960022472 creator A5025839745 @default.
• W2960022472 creator A5036678155 @default.
• W2960022472 creator A5037060961 @default.
• W2960022472 creator A5054443227 @default.
• W2960022472 creator A5083703980 @default.
• W2960022472 date "2019-07-15" @default.
• W2960022472 modified "2023-10-12" @default.
• W2960022472 title "APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC" @default.
• W2960022472 cites W1555518714 @default.
• W2960022472 cites W1602460334 @default.
• W2960022472 cites W1701054940 @default.
• W2960022472 cites W1755597336 @default.
• W2960022472 cites W1832442421 @default.
• W2960022472 cites W1889691760 @default.
• W2960022472 cites W1972241251 @default.
• W2960022472 cites W1973449404 @default.
• W2960022472 cites W1976809239 @default.
• W2960022472 cites W1978228437 @default.
• W2960022472 cites W1978981036 @default.
• W2960022472 cites W1979862132 @default.
• W2960022472 cites W1984048017 @default.
• W2960022472 cites W1987702513 @default.
• W2960022472 cites W1990963919 @default.
• W2960022472 cites W1994750661 @default.
• W2960022472 cites W1998700068 @default.
• W2960022472 cites W2001866617 @default.
• W2960022472 cites W2012648997 @default.
• W2960022472 cites W2013661706 @default.
• W2960022472 cites W2017427749 @default.
• W2960022472 cites W2018066994 @default.
• W2960022472 cites W2019878915 @default.
• W2960022472 cites W2020165821 @default.
• W2960022472 cites W2020781844 @default.
• W2960022472 cites W2021187404 @default.
• W2960022472 cites W2021973292 @default.
• W2960022472 cites W2023111282 @default.
• W2960022472 cites W2023310753 @default.
• W2960022472 cites W2032054503 @default.
• W2960022472 cites W2037806375 @default.
• W2960022472 cites W2037896799 @default.
• W2960022472 cites W2038981426 @default.
• W2960022472 cites W2039898308 @default.
• W2960022472 cites W2041634882 @default.
• W2960022472 cites W2043515643 @default.
• W2960022472 cites W2048143514 @default.
• W2960022472 cites W2055488159 @default.
• W2960022472 cites W2056402768 @default.
• W2960022472 cites W2064102777 @default.
• W2960022472 cites W2068256033 @default.
• W2960022472 cites W2073131323 @default.
• W2960022472 cites W2080662322 @default.
• W2960022472 cites W2082318061 @default.
• W2960022472 cites W2082829202 @default.
• W2960022472 cites W2086369200 @default.
• W2960022472 cites W2087290238 @default.
• W2960022472 cites W2088110780 @default.
• W2960022472 cites W2089082191 @default.
• W2960022472 cites W2091405727 @default.
• W2960022472 cites W2092130062 @default.
• W2960022472 cites W2093215351 @default.
• W2960022472 cites W2107043033 @default.
• W2960022472 cites W2111495238 @default.
• W2960022472 cites W2114843025 @default.
• W2960022472 cites W2116760308 @default.
• W2960022472 cites W2120676861 @default.
• W2960022472 cites W2121186077 @default.
• W2960022472 cites W2124871299 @default.
• W2960022472 cites W2133253702 @default.
• W2960022472 cites W2134539328 @default.
• W2960022472 cites W2141434157 @default.
• W2960022472 cites W2144408606 @default.
• W2960022472 cites W2145415478 @default.
• W2960022472 cites W2149441684 @default.
• W2960022472 cites W2151593726 @default.
• W2960022472 cites W2151855684 @default.
• W2960022472 cites W2154027407 @default.
• W2960022472 cites W2154111088 @default.
• W2960022472 cites W2157294624 @default.
• W2960022472 cites W2159675211 @default.
• W2960022472 cites W2162874229 @default.
• W2960022472 cites W2164277862 @default.
• W2960022472 cites W2165378960 @default.
• W2960022472 cites W2167111315 @default.
• W2960022472 cites W2169589032 @default.
• W2960022472 cites W2199897229 @default.
• W2960022472 cites W2299201274 @default.
• W2960022472 cites W2309067861 @default.
• W2960022472 cites W2318028708 @default.
• W2960022472 cites W2318310371 @default.
• W2960022472 cites W2327197426 @default.
• W2960022472 cites W2334550692 @default.
• W2960022472 cites W2410808955 @default.
• W2960022472 cites W2561630075 @default.
• W2960022472 cites W2568859793 @default.
• W2960022472 cites W2597559961 @default.

• next