Matches in SemOpenAlex for { <https://semopenalex.org/work/W2960194872> ?p ?o ?g. }
- W2960194872 endingPage "102649" @default.
- W2960194872 startingPage "102649" @default.
- W2960194872 abstract "5-Formyl-2'-deoxycytidine (5fdC) is a naturally occurring nucleobase that is broadly distributed in genomic DNA. 5fdC is produced via the oxidation of 5-methylcytosine (5mdC) by ten-eleven translocation enzyme (TET) and can be further converted to 5-carboxylcytosine (5cadC) by TET. Both 5fdC and 5cadC can be restored to dC by TDG-mediated base excision repair and direct deformylation/decarboxylation. Thus, 5fdC is considered an intermediate in the TET-mediated DNA demethylation pathway. 5fdC also alters the structure and stability of genomic DNA and affects genetic expression. This review summarizes the recent research on 5fdC, detailing its formation, detection and distribution, biological functions and transformation in cells. The challenges and future prospects to further explore the function and metabolism of 5fdC are briefly discussed at the end." @default.
- W2960194872 created "2019-07-23" @default.
- W2960194872 creator A5028026426 @default.
- W2960194872 creator A5089622339 @default.
- W2960194872 date "2019-09-01" @default.
- W2960194872 modified "2023-10-08" @default.
- W2960194872 title "Formation and biological consequences of 5-Formylcytosine in genomic DNA" @default.
- W2960194872 cites W1422283187 @default.
- W2960194872 cites W1503311137 @default.
- W2960194872 cites W1521888731 @default.
- W2960194872 cites W1790956234 @default.
- W2960194872 cites W1968584162 @default.
- W2960194872 cites W1971320754 @default.
- W2960194872 cites W1979273476 @default.
- W2960194872 cites W1983910249 @default.
- W2960194872 cites W1984066495 @default.
- W2960194872 cites W1984783889 @default.
- W2960194872 cites W1986908628 @default.
- W2960194872 cites W1987658864 @default.
- W2960194872 cites W1993145571 @default.
- W2960194872 cites W1997453048 @default.
- W2960194872 cites W1998028181 @default.
- W2960194872 cites W2000225203 @default.
- W2960194872 cites W2001728345 @default.
- W2960194872 cites W2004875218 @default.
- W2960194872 cites W2005583321 @default.
- W2960194872 cites W2006821116 @default.
- W2960194872 cites W2015586003 @default.
- W2960194872 cites W2020734526 @default.
- W2960194872 cites W2021621793 @default.
- W2960194872 cites W2026255880 @default.
- W2960194872 cites W2029004484 @default.
- W2960194872 cites W2030777556 @default.
- W2960194872 cites W2031137745 @default.
- W2960194872 cites W2036662877 @default.
- W2960194872 cites W2038449573 @default.
- W2960194872 cites W2048940179 @default.
- W2960194872 cites W2054752346 @default.
- W2960194872 cites W2073105380 @default.
- W2960194872 cites W2075151834 @default.
- W2960194872 cites W2075563645 @default.
- W2960194872 cites W2076255761 @default.
- W2960194872 cites W2078957174 @default.
- W2960194872 cites W2082063940 @default.
- W2960194872 cites W2082883238 @default.
- W2960194872 cites W2088650930 @default.
- W2960194872 cites W2099318737 @default.
- W2960194872 cites W2102083376 @default.
- W2960194872 cites W2104687676 @default.
- W2960194872 cites W2106482872 @default.
- W2960194872 cites W2108664872 @default.
- W2960194872 cites W2118844824 @default.
- W2960194872 cites W2121417064 @default.
- W2960194872 cites W2129270269 @default.
- W2960194872 cites W2132199053 @default.
- W2960194872 cites W2132493174 @default.
- W2960194872 cites W2134349183 @default.
- W2960194872 cites W2144962102 @default.
- W2960194872 cites W2147001139 @default.
- W2960194872 cites W2152451432 @default.
- W2960194872 cites W2153603647 @default.
- W2960194872 cites W2156295197 @default.
- W2960194872 cites W2156386262 @default.
- W2960194872 cites W2157127796 @default.
- W2960194872 cites W2157458089 @default.
- W2960194872 cites W2161326542 @default.
- W2960194872 cites W2169639150 @default.
- W2960194872 cites W2171490882 @default.
- W2960194872 cites W2196560216 @default.
- W2960194872 cites W2246141446 @default.
- W2960194872 cites W2320498187 @default.
- W2960194872 cites W2324058856 @default.
- W2960194872 cites W2325044073 @default.
- W2960194872 cites W2325442812 @default.
- W2960194872 cites W2409146838 @default.
- W2960194872 cites W2498346432 @default.
- W2960194872 cites W2517327266 @default.
- W2960194872 cites W2590641123 @default.
- W2960194872 cites W2591367881 @default.
- W2960194872 cites W2599498000 @default.
- W2960194872 cites W2613613516 @default.
- W2960194872 cites W2735962445 @default.
- W2960194872 cites W2736809432 @default.
- W2960194872 cites W2752300912 @default.
- W2960194872 cites W2752723776 @default.
- W2960194872 cites W2757739379 @default.
- W2960194872 cites W2765495909 @default.
- W2960194872 cites W2768929279 @default.
- W2960194872 cites W2783660721 @default.
- W2960194872 cites W2793471977 @default.
- W2960194872 cites W2802778916 @default.
- W2960194872 cites W2808383642 @default.
- W2960194872 cites W2883632697 @default.
- W2960194872 cites W2895991294 @default.
- W2960194872 cites W2922026077 @default.
- W2960194872 cites W2924857274 @default.
- W2960194872 doi "https://doi.org/10.1016/j.dnarep.2019.102649" @default.
- W2960194872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31303545" @default.