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- W2960209230 abstract "The Machilus genus (Lauraceae) had been extensively utilized in folk medicine due to its broad range of bioactivities. In the present study, a series of chromatographic separations of the methanol extract of stems of M. philippinensis led to the identification of thirty eight compounds totally. Among these, biscinnamophilin (1), machilupins A-C (2-4), machilutone A (5), and machilusoxide A (6) were new compounds reported for the first time. In addition, 5 was characterized with a unprecedented carbon skeleton. Other known compounds, including the major compounds cinnamophilin (7) and meso-dihydroguaiaretic acid (8), are identified by comparison of their physical and spectroscopic data with reported values. One of the reported compounds, cinnamophilin A (10), should be revised as dehydroguaiaretic acid (9) after careful comparison of all the 1H and 13C NMR data. Moreover, the neuroprotective activity of cinnamophilin (7) was examined in a primary cortical neuron culture and the results indicated that 7 was effective against glutamate induced excitotoxicity." @default.
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- W2960209230 date "2019-01-01" @default.
- W2960209230 modified "2023-09-25" @default.
- W2960209230 title "Chemical constituents from the stems of <i>Machilus philippinensis</i> Merr. and the neuroprotective activity of cinnamophilin" @default.
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- W2960209230 doi "https://doi.org/10.1039/c9ra03514a" @default.
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