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• W2960293679 abstract "Pediatric anaplastic large-cell lymphoma (ALCL), which is characterized by strong expression of CD30, is usually responsive to multidrug chemotherapy. Brentuximab vedotin (BV) which is an anti-CD30 antibody-drug conjugate is a promising drug with effects on relapsing or refractory ALCL. However, its effects may not be sufficient for the central nervous system disease. The authors herein reported an 11-year-old boy with ALCL that progressed as central nervous system disease receiving intensive induction chemotherapy has achieved and maintained remission by BV and high-dose methotrexate administrated alternately. Alternate therapy with high-dose methotrexate may complement these shortcomings of BV to provide safe treatment without worsening adverse events." @default.
• W2960293679 created "2019-07-23" @default.
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• W2960293679 date "2019-07-03" @default.
• W2960293679 modified "2023-09-28" @default.
• W2960293679 title "Brentuximab Vedotin and High-dose Methotrexate Administrated Alternately for Refractory Anaplastic Large-cell Lymphoma With Central Nervous System Disease" @default.
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• W2960293679 doi "https://doi.org/10.1097/mph.0000000000001550" @default.
• W2960293679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31274669" @default.
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