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- W2960391625 abstract "Significance The 4 intravenous anesthetics currently in clinical use are associated with undesirable side effects such as lower blood pressure. These agents are poorly tolerated in young and elderly patients, limiting their use and increasing their risks. Additionally, etomidate, an anesthetic that achieves stable cardiovascular conditions, causes significant adrenal suppression by inhibiting steroid biosynthesis. Even though the exact mechanisms of anesthesia remain unknown, a significant component appears to be mediated by γ-aminobutyric acid type A receptors (GABA A Rs). By targeting an anesthetic binding site in these receptors, we are designing anesthetics with reduced side effects. A unique agent based on this design is now shown to be potent and selective for GABA A -slow receptors and produces anesthesia with minimal hemodynamic side effects." @default.
- W2960391625 created "2019-07-23" @default.
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- W2960391625 date "2019-07-15" @default.
- W2960391625 modified "2023-10-18" @default.
- W2960391625 title "A newly developed anesthetic based on a unique chemical core" @default.
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- W2960391625 doi "https://doi.org/10.1073/pnas.1822076116" @default.
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