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- W2960393348 endingPage "5757" @default.
- W2960393348 startingPage "5730" @default.
- W2960393348 abstract "Mitochondria are key players with a multi-functional role in many vital cellular processes, such as energy metabolism, redox regulation, calcium homeostasis, Reactive Oxygen Species (ROS) as well as in cell signaling, survival and apoptosis. These functions are mainly regulated through important enzyme signaling cascades, which if altered may influence the outcome of cell viability and apoptosis. Therefore some of the key enzymes that are vital for these signaling pathways are emerging as important targets for new anticancer agent development. Mitocans are compounds aimed at targeting mitochondria in cancer cells by altering mitochondrial functions thus causing cell growth inhibition or apoptosis. This review summarizes the till present known classes of mitocans, their mechanism of action and potential therapeutic use in different forms of cancer." @default.
- W2960393348 created "2019-07-23" @default.
- W2960393348 creator A5015552254 @default.
- W2960393348 creator A5037899421 @default.
- W2960393348 creator A5050827290 @default.
- W2960393348 creator A5062850407 @default.
- W2960393348 creator A5063244624 @default.
- W2960393348 creator A5069374106 @default.
- W2960393348 creator A5069978992 @default.
- W2960393348 creator A5072303941 @default.
- W2960393348 date "2020-10-11" @default.
- W2960393348 modified "2023-10-18" @default.
- W2960393348 title "Targeting Mitochondria through the Use of Mitocans as Emerging Anticancer Agents" @default.
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