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• W2960484841 endingPage "1023" @default.
• W2960484841 startingPage "1005" @default.
• W2960484841 abstract "Longitudinal research suggests that genetic, lifestyle, and environmental factors enhance one's risk for developing Alzheimer's disease and related dementias (ADRD). However, it is not known how an accumulation of such factors impact brain functioning. One barrier to this research is that increased risk for ADRD affects the cerebrovascular system and, therefore, alters the link between neural activity and the fMRI BOLD signal. To better interpret fMRI findings, several steps were taken to adjust fMRI activity thereby reducing such cerebrovascular effects. We hypothesized that as the number of ADRD risk factors increase, brain regions within the medial temporal lobes and the default mode network would exhibit altered brain activity during an episodic memory retrieval task. Middle-aged and older adults (aged 50-74) free of dementia were recruited with varying levels of risk and underwent a neuropsychological battery and fMRI. In the memory task, participants viewed a pair of pictures. In an alternative-forced-choice test, participants viewed a picture cue and had to determine which of four pictures was paired with the cue. Increased dementia risk was positively associated with brain activity in regions of interest within the default mode network, the hippocampus, and the entorhinal cortex during memory retrieval. Whole-brain analyses revealed additional positive associations in prefrontal and occipito-temporal cortices. Risk factors most contributing to these elevated levels of brain activity included hypertension, diabetes, obesity, and cholesterol. We also ruled out confounds due to in-scanner performance and premorbid ability. Cumulative risk might represent early signs of burnout in brain regions underlying episodic memory." @default.
• W2960484841 created "2019-07-23" @default.
• W2960484841 creator A5053795239 @default.
• W2960484841 creator A5076218765 @default.
• W2960484841 creator A5085099997 @default.
• W2960484841 date "2019-08-20" @default.
• W2960484841 modified "2023-09-24" @default.
• W2960484841 title "Dementia Risk Elevates Brain Activity During Memory Retrieval: A Functional MRI Analysis of Middle Aged and Older Adults" @default.
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• W2960484841 doi "https://doi.org/10.3233/jad-190035" @default.
• W2960484841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31306118" @default.
• W2960484841 hasPublicationYear "2019" @default.

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