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- W2960489192 abstract "Purpose of review The purpose of this review is to summarize the diagnosis and management of the antiphospholipid syndrome (APS) in children. Recent findings APS is a rare, acquired autoimmune systemic disease that can result in significant morbidity in children related to vascular thrombosis. The diagnosis and management of APS in children can be challenging due to a lack of validated diagnostic criteria and the rarity of the disease. In addition, many healthy children have transient circulating antiphospholipid antibodies without thrombotic complications. Nevertheless, epidemiological studies suggest that APS represents a greater relative proportion of thrombotic disease in children than it does in adults. Management of pediatric APS is largely inferred from adult data despite unique characteristics of pediatric APS. The current recommendations include long-term anticoagulation, which can be problematic in young, active individuals. There is little data on potential benefits of nonantithrombotic therapy in the management of pediatric APS. Summary Data on pediatric APS are limited, but evidence suggests that using current available diagnostic testing is valuable and, until further evidence is available, treating thrombotic complications with heparins or warfarin should be standard of care." @default.
- W2960489192 created "2019-07-23" @default.
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- W2960489192 date "2019-09-01" @default.
- W2960489192 modified "2023-09-27" @default.
- W2960489192 title "Antiphospholipid syndrome in pediatric patients" @default.
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- W2960489192 doi "https://doi.org/10.1097/moh.0000000000000523" @default.
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