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• W2960493091 abstract "Objective: To investigate annualized whole-brain atrophy rates (a-WBAR) in idiopathic Parkinson’s disease IPD, multiple system atrophy and progressive supranuclear palsy (PSP) as an aid to clinical diagnosis between IPD and the aggressive PSP and MSA. Background: The absence of markers for ante-mortem diagnosis of PSP and MSA results in these disorders’ being commonly mistaken for IPD. No neuroimaging modalities are specifically recommended for routine use in clinical practice in the differential diagnosis between IPD and these parkinson plus syndromes. Design/Methods: Internationally established operational criteria were used to assess the diagnoses of MSA, PSP and IPD. Ten healthy controls, 20 IPD, 39 PSP and 41 MSA patients were studied using the Structural Imaging Evaluation with Normalization of Atrophy (SIENA). SIENA is a MRI-based algorithm that quantifies brain tissue volume and does not requiere radiotracers. SIENA has been shown to have 0.5% brain volume accuracy in longitudinal studies. Results: There were no significant differences in age, gender and disease duration between IPD and these parkinson plus variants. In controls, the a-WBAR was 0.37%±0.28 (CI 95% 0.17–0.57), while in IPD a-WBAR was 0.5%± 0.38 (CI 95% 0.32–0.68). The IPD patients did not differ from the controls. In PSP, the a-WBAR was 1.9% ± 1.15 (CI 95% 1.37–1.93). In MSA a-WBAR was 1.65 % ± 0.9 (CI 95% 1.5–2.2). MSA did not differ from PSP. The a-WBAR in PSP and MSA were significantly higher than in the IPD group (p 0.6% differentiated patients with PSA and MSA from those with IPD with 91% sensitivity and 80% specificity. Conclusions: a-WBAR within normal range is unlikely to be observed in PSP or MSA. a-WBAR may add a potential retrospective application to improve the diagnostic accuracy of MSA and PSP vs. IPD, particularly in the initial stages, when ‘plus syndrome’ has not yet clinically emerged. Study Supported by: FONDECYT 11121212, CHILE Disclosure: Dr. Guevara Oliva has nothing to disclose. Dr. Bulatova has nothing to disclose." @default.
• W2960493091 created "2019-07-23" @default.
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• W2960493091 date "2017-04-18" @default.
• W2960493091 modified "2023-09-24" @default.
• W2960493091 title "Whole-brain atrophy rates add a retrospective application to improve the diagnostic accuracy of multiple system atrophy and progressive supranuclear palsy vs idiopathic Parkinson’s disease (P4.016)" @default.
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