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• W2960497798 startingPage "582" @default.
• W2960497798 abstract "Background Few studies have examined the associations between physical activity (PA), sedentary behaviour (SB) and risk of colorectal neoplasia (CN). Methods We systematically searched Medline, Embase, PsyInfo, Cochrane and other sources from their inception to 30 September 2018 for cohort, case-control and cross-sectional studies that evaluated these associations in asymptomatic, average-risk subjects. Random-effect models were used to estimate relative risks (RRs) of any-type CN, advanced CN, and non-advanced CN, respectively, in individuals with the highest versus the lowest level of PA and SB. Dose-response analyses and subgroup analyses were conducted. The I 2 statistic was used to examine heterogeneity among studies. Results We identified 32 observational studies, including 17 cross-sectional studies, 10 case-control studies and five longitudinal studies. PA (highest vs lowest) was inversely associated with risk for any-type CN (n=23 studies) and advanced CN (n=15 studies), with a RR of 0.77 (95% CI=0.71 to 0.83, I 2 =57.5%) and 0.73 (95% CI=0.63 to 0.82, I 2 =45.5%), respectively. There was no association between PA and non-advanced CN (n=5 studies). There was an as association between PA and any-type CN in both sexes, and also for the distal colon. We found no dose–response relationship between PA and any-type or advanced CN. Based on three studies identified, SB time (longest vs shortest) was associated with an increased risk of advanced CN (RR=1.24, 95% CI 1.04 to 1.49, I 2 =14.4%). No publication bias was detected by Begg’s test. Conclusion We report a 23% lower relative risk of any type of CN and a 27% lower risk of advanced CN in people with the highest level of PA compared with those in the lowest." @default.
• W2960497798 created "2019-07-23" @default.
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• W2960497798 date "2019-07-11" @default.
• W2960497798 modified "2023-10-17" @default.
• W2960497798 title "Physically active individuals have a 23% lower risk of any colorectal neoplasia and a 27% lower risk of advanced colorectal neoplasia than their non-active counterparts: systematic review and meta-analysis of observational studies" @default.
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• W2960497798 doi "https://doi.org/10.1136/bjsports-2018-100350" @default.
• W2960497798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31296585" @default.
• W2960497798 hasPublicationYear "2019" @default.
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