Matches in SemOpenAlex for { <https://semopenalex.org/work/W2960541806> ?p ?o ?g. }
- W2960541806 endingPage "109184" @default.
- W2960541806 startingPage "109184" @default.
- W2960541806 abstract "With the elderly population rapidly growing, the prevalence of Parkinson’s disease (PD) is quickly increasing because neurodegenerative disorders are usually late-onset. Herbal medicines and formula are adjuvant therapies of conventional PD agents, which result in serious side effects with long-term use. This study evaluated the neuroprotective effects of DA-9805, a standardized herbal formula that consists of an ethanolic extract of Moutan Cortex Radix, Angelica Dahuricae Radix, and Bupleuri Radix against 6-hydroxydopamine (6-OHDA)-induced cytotoxicity in vitro and in vivo. In PC12 cells, DA-9805 at concentrations of 1 and 10 μg/mL ameliorated cell viability, which was reduced by 6-OHDA. In addition, DA-9805 activated the extracellular-regulated kinase-nuclear transcription factor-erythroid 2-related factor 2 pathway, subsequently stimulating antioxidative enzymes such as NAD(P)H:quinone oxidoreductase 1 and catalase and suppressing apoptosis. Furthermore, DA-9805 prevented 6-OHDA-induced movement impairment, as well as a decrease of dopaminergic neurons and dopamine transmission in rodents. Taken together, these results suggest that the mixed herbal formula DA-9805 may be a pharmaceutical agent for preventing or improving PD." @default.
- W2960541806 created "2019-07-23" @default.
- W2960541806 creator A5002179767 @default.
- W2960541806 creator A5041899584 @default.
- W2960541806 creator A5042905337 @default.
- W2960541806 creator A5047885323 @default.
- W2960541806 creator A5049214550 @default.
- W2960541806 creator A5053630467 @default.
- W2960541806 creator A5056836759 @default.
- W2960541806 creator A5064949414 @default.
- W2960541806 creator A5065878504 @default.
- W2960541806 creator A5074087172 @default.
- W2960541806 creator A5082325472 @default.
- W2960541806 date "2019-09-01" @default.
- W2960541806 modified "2023-10-16" @default.
- W2960541806 title "Protective effects of DA-9805 on dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity in the models of Parkinson’s disease" @default.
- W2960541806 cites W1015875924 @default.
- W2960541806 cites W1588992136 @default.
- W2960541806 cites W1967659552 @default.
- W2960541806 cites W1970970384 @default.
- W2960541806 cites W1973409164 @default.
- W2960541806 cites W1978636570 @default.
- W2960541806 cites W1984879946 @default.
- W2960541806 cites W1985031521 @default.
- W2960541806 cites W1987353444 @default.
- W2960541806 cites W1989309117 @default.
- W2960541806 cites W2010290489 @default.
- W2960541806 cites W2017009693 @default.
- W2960541806 cites W2021432299 @default.
- W2960541806 cites W2023099428 @default.
- W2960541806 cites W2034173353 @default.
- W2960541806 cites W2037155454 @default.
- W2960541806 cites W2038691856 @default.
- W2960541806 cites W2044627978 @default.
- W2960541806 cites W2050755811 @default.
- W2960541806 cites W2052085642 @default.
- W2960541806 cites W2064428225 @default.
- W2960541806 cites W2069438897 @default.
- W2960541806 cites W2072550438 @default.
- W2960541806 cites W2079856528 @default.
- W2960541806 cites W2110356212 @default.
- W2960541806 cites W2135719628 @default.
- W2960541806 cites W2137744200 @default.
- W2960541806 cites W2144102286 @default.
- W2960541806 cites W2156179625 @default.
- W2960541806 cites W2160745208 @default.
- W2960541806 cites W2220077944 @default.
- W2960541806 cites W2345838873 @default.
- W2960541806 cites W2401820359 @default.
- W2960541806 cites W2408940410 @default.
- W2960541806 cites W2417001119 @default.
- W2960541806 cites W2509845469 @default.
- W2960541806 cites W2532286941 @default.
- W2960541806 cites W2754740801 @default.
- W2960541806 cites W2807082348 @default.
- W2960541806 cites W2896502644 @default.
- W2960541806 cites W4213459747 @default.
- W2960541806 doi "https://doi.org/10.1016/j.biopha.2019.109184" @default.
- W2960541806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31387167" @default.
- W2960541806 hasPublicationYear "2019" @default.
- W2960541806 type Work @default.
- W2960541806 sameAs 2960541806 @default.
- W2960541806 citedByCount "11" @default.
- W2960541806 countsByYear W29605418062020 @default.
- W2960541806 countsByYear W29605418062021 @default.
- W2960541806 countsByYear W29605418062022 @default.
- W2960541806 countsByYear W29605418062023 @default.
- W2960541806 crossrefType "journal-article" @default.
- W2960541806 hasAuthorship W2960541806A5002179767 @default.
- W2960541806 hasAuthorship W2960541806A5041899584 @default.
- W2960541806 hasAuthorship W2960541806A5042905337 @default.
- W2960541806 hasAuthorship W2960541806A5047885323 @default.
- W2960541806 hasAuthorship W2960541806A5049214550 @default.
- W2960541806 hasAuthorship W2960541806A5053630467 @default.
- W2960541806 hasAuthorship W2960541806A5056836759 @default.
- W2960541806 hasAuthorship W2960541806A5064949414 @default.
- W2960541806 hasAuthorship W2960541806A5065878504 @default.
- W2960541806 hasAuthorship W2960541806A5074087172 @default.
- W2960541806 hasAuthorship W2960541806A5082325472 @default.
- W2960541806 hasBestOaLocation W29605418061 @default.
- W2960541806 hasConcept C126322002 @default.
- W2960541806 hasConcept C137183658 @default.
- W2960541806 hasConcept C185592680 @default.
- W2960541806 hasConcept C25498285 @default.
- W2960541806 hasConcept C2779134260 @default.
- W2960541806 hasConcept C2779491297 @default.
- W2960541806 hasConcept C2779734285 @default.
- W2960541806 hasConcept C2911016594 @default.
- W2960541806 hasConcept C29730261 @default.
- W2960541806 hasConcept C513476851 @default.
- W2960541806 hasConcept C71924100 @default.
- W2960541806 hasConcept C98274493 @default.
- W2960541806 hasConceptScore W2960541806C126322002 @default.
- W2960541806 hasConceptScore W2960541806C137183658 @default.
- W2960541806 hasConceptScore W2960541806C185592680 @default.
- W2960541806 hasConceptScore W2960541806C25498285 @default.
- W2960541806 hasConceptScore W2960541806C2779134260 @default.
- W2960541806 hasConceptScore W2960541806C2779491297 @default.