Matches in SemOpenAlex for { <https://semopenalex.org/work/W2960561537> ?p ?o ?g. }
- W2960561537 endingPage "289" @default.
- W2960561537 startingPage "289" @default.
- W2960561537 abstract "The modulation of the activity of DNA methyltransferases (DNMTs) represents a crucial epigenetic mechanism affecting gene expressions or DNA repair mechanisms in the cells. Aberrant modifications in the function of DNMTs are a fundamental event and part of the pathogenesis of human cancer. Phytochemicals, which are biosynthesized in plants in the form of secondary metabolites, represent an important source of biomolecules with pleiotropic effects and thus provide a wide range of possible clinical applications. It is well documented that phytochemicals demonstrate significant anticancer properties, and in this regard, rapid development within preclinical research is encouraging. Phytochemicals affect several epigenetic molecular mechanisms, including DNA methylation patterns such as the hypermethylation of tumor-suppressor genes and the global hypomethylation of oncogenes, that are specific cellular signs of cancer development and progression. This review will focus on the latest achievements in using plant-derived compounds and plant-based diets targeting epigenetic regulators and modulators of gene transcription in preclinical and clinical research in order to generate novel anticancer drugs as sensitizers for conventional therapy or compounds suitable for the chemoprevention clinical setting in at-risk individuals. In conclusion, indisputable anticancer activities of dietary phytochemicals linked with proper regulation of DNA methylation status have been described. However, precisely designed and well-controlled clinical studies are needed to confirm their beneficial epigenetic effects after long-term consumption in humans." @default.
- W2960561537 created "2019-07-23" @default.
- W2960561537 creator A5000050616 @default.
- W2960561537 creator A5014077208 @default.
- W2960561537 creator A5014124558 @default.
- W2960561537 creator A5017719757 @default.
- W2960561537 creator A5023771868 @default.
- W2960561537 creator A5030441119 @default.
- W2960561537 creator A5033886573 @default.
- W2960561537 creator A5034326759 @default.
- W2960561537 creator A5039379906 @default.
- W2960561537 creator A5045923633 @default.
- W2960561537 creator A5065388065 @default.
- W2960561537 creator A5084414618 @default.
- W2960561537 creator A5086763207 @default.
- W2960561537 creator A5089886023 @default.
- W2960561537 date "2019-07-18" @default.
- W2960561537 modified "2023-10-04" @default.
- W2960561537 title "DNA Methylation Status in Cancer Disease: Modulations by Plant-Derived Natural Compounds and Dietary Interventions" @default.
- W2960561537 cites W1484570329 @default.
- W2960561537 cites W1508618141 @default.
- W2960561537 cites W1569673965 @default.
- W2960561537 cites W1572223496 @default.
- W2960561537 cites W1598239887 @default.
- W2960561537 cites W1738220681 @default.
- W2960561537 cites W1787774280 @default.
- W2960561537 cites W1904095165 @default.
- W2960561537 cites W1926976583 @default.
- W2960561537 cites W1938133189 @default.
- W2960561537 cites W1939667010 @default.
- W2960561537 cites W1967178356 @default.
- W2960561537 cites W1969486892 @default.
- W2960561537 cites W1971943164 @default.
- W2960561537 cites W1976726102 @default.
- W2960561537 cites W1979024723 @default.
- W2960561537 cites W1981585472 @default.
- W2960561537 cites W1991982333 @default.
- W2960561537 cites W2008665179 @default.
- W2960561537 cites W2013253758 @default.
- W2960561537 cites W2014936297 @default.
- W2960561537 cites W2029933341 @default.
- W2960561537 cites W2036830903 @default.
- W2960561537 cites W2044020682 @default.
- W2960561537 cites W2048338967 @default.
- W2960561537 cites W2062190843 @default.
- W2960561537 cites W2064149487 @default.
- W2960561537 cites W2068669644 @default.
- W2960561537 cites W2069289315 @default.
- W2960561537 cites W2075066001 @default.
- W2960561537 cites W2080261166 @default.
- W2960561537 cites W2084203180 @default.
- W2960561537 cites W2087102857 @default.
- W2960561537 cites W2092003419 @default.
- W2960561537 cites W2105389498 @default.
- W2960561537 cites W2110881699 @default.
- W2960561537 cites W2121003886 @default.
- W2960561537 cites W2122331874 @default.
- W2960561537 cites W2124176680 @default.
- W2960561537 cites W2124923086 @default.
- W2960561537 cites W2130198345 @default.
- W2960561537 cites W2139002248 @default.
- W2960561537 cites W2139620481 @default.
- W2960561537 cites W2148693352 @default.
- W2960561537 cites W2149816812 @default.
- W2960561537 cites W2156850730 @default.
- W2960561537 cites W2159552814 @default.
- W2960561537 cites W2167637569 @default.
- W2960561537 cites W2231664225 @default.
- W2960561537 cites W2232015008 @default.
- W2960561537 cites W2244073676 @default.
- W2960561537 cites W2258255719 @default.
- W2960561537 cites W2289157900 @default.
- W2960561537 cites W2302407022 @default.
- W2960561537 cites W2338146147 @default.
- W2960561537 cites W2341062931 @default.
- W2960561537 cites W2345649975 @default.
- W2960561537 cites W2361356621 @default.
- W2960561537 cites W2396936815 @default.
- W2960561537 cites W2460215708 @default.
- W2960561537 cites W2472906944 @default.
- W2960561537 cites W2512901794 @default.
- W2960561537 cites W2513730937 @default.
- W2960561537 cites W2515644879 @default.
- W2960561537 cites W2520787228 @default.
- W2960561537 cites W2520894026 @default.
- W2960561537 cites W2526981126 @default.
- W2960561537 cites W2550496747 @default.
- W2960561537 cites W2562416289 @default.
- W2960561537 cites W2583737043 @default.
- W2960561537 cites W2585344729 @default.
- W2960561537 cites W2592500806 @default.
- W2960561537 cites W2593320405 @default.
- W2960561537 cites W2597594016 @default.
- W2960561537 cites W2606622374 @default.
- W2960561537 cites W2606903365 @default.
- W2960561537 cites W2607048704 @default.
- W2960561537 cites W2611563138 @default.
- W2960561537 cites W2614518936 @default.