Matches in SemOpenAlex for { <https://semopenalex.org/work/W2960602181> ?p ?o ?g. }
- W2960602181 endingPage "110768" @default.
- W2960602181 startingPage "110768" @default.
- W2960602181 abstract "Organometallic compounds based on bioactive ligand systems have shown promising antiproliferative properties. The use of 8-hydroxyquinoline and its derivatives as bioactive ligands resulted in organometallic complexes with potent anticancer activity, but they lack aqueous solubility for further development. We report here the preparation of a series of MII/III(cym/Cp*)Cl complexes (η6-p-cymene (cym): M = Ru, Os; η5-pentamethylcyclopentadienyl (Cp*): M = Rh, Ir) with hydroxyquinoline-derived co-ligands and in a subsequent step the substitution of the chlorido ligands for amphiphilic 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane (PTA). Solubility studies indicated that the introduced PTA ligand significantly improved the aqueous solubility of all complexes. The complexes were shown to be stable in aqueous and DMSO solution over a period of at least 3 d. As would be expected for such modification of complexes, the higher solubility resulted in significantly decreased cytotoxicity in cancer cells. The antiproliferative activity was still more pronounced than that of RAPTA-C [Ru(cym)(PTA)Cl] which, however, has been demonstrated to have antimetastatic and antiangiogenic properties in vivo." @default.
- W2960602181 created "2019-07-23" @default.
- W2960602181 creator A5016416113 @default.
- W2960602181 creator A5025677067 @default.
- W2960602181 creator A5034298969 @default.
- W2960602181 creator A5066863762 @default.
- W2960602181 creator A5067190736 @default.
- W2960602181 creator A5078146193 @default.
- W2960602181 creator A5086697134 @default.
- W2960602181 creator A5087288813 @default.
- W2960602181 date "2019-10-01" @default.
- W2960602181 modified "2023-10-16" @default.
- W2960602181 title "Hydroxyquinoline-derived anticancer organometallics: Introduction of amphiphilic PTA as an ancillary ligand increases their aqueous solubility" @default.
- W2960602181 cites W1178498256 @default.
- W2960602181 cites W1491350259 @default.
- W2960602181 cites W1913609759 @default.
- W2960602181 cites W1964918746 @default.
- W2960602181 cites W1987039564 @default.
- W2960602181 cites W1996834020 @default.
- W2960602181 cites W2002015225 @default.
- W2960602181 cites W2021527389 @default.
- W2960602181 cites W2025084882 @default.
- W2960602181 cites W2035736203 @default.
- W2960602181 cites W2040727845 @default.
- W2960602181 cites W2050077837 @default.
- W2960602181 cites W2051341669 @default.
- W2960602181 cites W2055286653 @default.
- W2960602181 cites W2059205366 @default.
- W2960602181 cites W2064894863 @default.
- W2960602181 cites W2069305928 @default.
- W2960602181 cites W2070625765 @default.
- W2960602181 cites W2073057404 @default.
- W2960602181 cites W2077987172 @default.
- W2960602181 cites W2086627300 @default.
- W2960602181 cites W2096290386 @default.
- W2960602181 cites W2097248275 @default.
- W2960602181 cites W2103459003 @default.
- W2960602181 cites W2111986931 @default.
- W2960602181 cites W2118343698 @default.
- W2960602181 cites W2122622156 @default.
- W2960602181 cites W2127618819 @default.
- W2960602181 cites W2128410748 @default.
- W2960602181 cites W2131350133 @default.
- W2960602181 cites W2142787097 @default.
- W2960602181 cites W2149451102 @default.
- W2960602181 cites W2152085763 @default.
- W2960602181 cites W2157109780 @default.
- W2960602181 cites W2287352880 @default.
- W2960602181 cites W2346158019 @default.
- W2960602181 cites W2419256959 @default.
- W2960602181 cites W2538688082 @default.
- W2960602181 cites W2588119080 @default.
- W2960602181 cites W2595617894 @default.
- W2960602181 cites W2750955617 @default.
- W2960602181 cites W2770473333 @default.
- W2960602181 cites W2783125373 @default.
- W2960602181 cites W2787270596 @default.
- W2960602181 cites W2789952534 @default.
- W2960602181 cites W2793534790 @default.
- W2960602181 cites W2810639441 @default.
- W2960602181 cites W2896130004 @default.
- W2960602181 cites W2910333849 @default.
- W2960602181 cites W2910941984 @default.
- W2960602181 cites W2923478028 @default.
- W2960602181 doi "https://doi.org/10.1016/j.jinorgbio.2019.110768" @default.
- W2960602181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31357065" @default.
- W2960602181 hasPublicationYear "2019" @default.
- W2960602181 type Work @default.
- W2960602181 sameAs 2960602181 @default.
- W2960602181 citedByCount "30" @default.
- W2960602181 countsByYear W29606021812019 @default.
- W2960602181 countsByYear W29606021812020 @default.
- W2960602181 countsByYear W29606021812021 @default.
- W2960602181 countsByYear W29606021812022 @default.
- W2960602181 countsByYear W29606021812023 @default.
- W2960602181 crossrefType "journal-article" @default.
- W2960602181 hasAuthorship W2960602181A5016416113 @default.
- W2960602181 hasAuthorship W2960602181A5025677067 @default.
- W2960602181 hasAuthorship W2960602181A5034298969 @default.
- W2960602181 hasAuthorship W2960602181A5066863762 @default.
- W2960602181 hasAuthorship W2960602181A5067190736 @default.
- W2960602181 hasAuthorship W2960602181A5078146193 @default.
- W2960602181 hasAuthorship W2960602181A5086697134 @default.
- W2960602181 hasAuthorship W2960602181A5087288813 @default.
- W2960602181 hasConcept C109316439 @default.
- W2960602181 hasConcept C116569031 @default.
- W2960602181 hasConcept C155574463 @default.
- W2960602181 hasConcept C155647269 @default.
- W2960602181 hasConcept C15920480 @default.
- W2960602181 hasConcept C170493617 @default.
- W2960602181 hasConcept C178790620 @default.
- W2960602181 hasConcept C184651966 @default.
- W2960602181 hasConcept C185592680 @default.
- W2960602181 hasConcept C197404232 @default.
- W2960602181 hasConcept C202751555 @default.
- W2960602181 hasConcept C21951064 @default.
- W2960602181 hasConcept C521977710 @default.
- W2960602181 hasConcept C55493867 @default.