FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2960609774> ?p ?o ?g. }

• W2960609774 endingPage "121716" @default.
• W2960609774 startingPage "121716" @default.
• W2960609774 abstract "Poly(ethylene glycol)- block -poly(lactic acid) (PEG-PLA) is a biocompatible and amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic PLA block, which can self-assemble into micelles in water. It is one of the most commonly used biodegradable polymers for drug encapsulation, drug solubilization and drug delivery. Due to the complexity and heterogeneity of PEG-PLA, the precise analysis of this polymer is a great challenge. This study reports an application of an UPLC tandem mass spectrometry coupled with in-source collision induced dissociation (CID) technique for the analysis of a model compound mPEG2000-PDLLA2500-COOH, which could be dissociated in source and generate a series of fragment ions corresponding to its subunits. These surrogate ions including PLA-specific and PEG-specific fragment ions could be further broken into specific product ions in collision cell. Finally, the ion transition at m / z 505.0 → 217.0 was selected for the quantitation of mPEG2000-PDLLA2500-COOH. This assay achieved a lower limit of quantitation (LLOQ) of 0.05 μg/mL with only 30 μL rat plasma. The linear range is 0.05 to 5 μg/mL. Intraday and interday accuracy and precision were within ±12.1%. The method was successfully applied to the pharmacokinetic study of mPEG2000-PDLLA2500-COOH in rats. The results revealed that LC-MS/MS coupled with in-source CID is a sensitive and specific strategy for analysis of PEG-PLA. This method can be potentially extended to the analysis of other pharmaceutical polymer excipients. • An UPLC-MS/MS method coupled with in-source CID for quantification of PEG-PLA. • Both PEG-specific and PLA-specific fragments could be used for analysis of PEG-PLA. • This assay has been successfully applied for PEG-PLA pharmacokinetic study in rats." @default.
• W2960609774 created "2019-07-23" @default.
• W2960609774 creator A5050152496 @default.
• W2960609774 creator A5066989187 @default.
• W2960609774 creator A5079553213 @default.
• W2960609774 creator A5082557734 @default.
• W2960609774 creator A5088214603 @default.
• W2960609774 date "2019-09-01" @default.
• W2960609774 modified "2023-10-12" @default.
• W2960609774 title "Development of an UPLC-MS/MS method coupled with in-source CID for quantitative analysis of PEG-PLA copolymer and its application to a pharmacokinetic study in rats" @default.
• W2960609774 cites W1969528174 @default.
• W2960609774 cites W1971602969 @default.
• W2960609774 cites W1984367237 @default.
• W2960609774 cites W1986824448 @default.
• W2960609774 cites W2034067478 @default.
• W2960609774 cites W2056442519 @default.
• W2960609774 cites W2091796668 @default.
• W2960609774 cites W2150895058 @default.
• W2960609774 cites W2202116730 @default.
• W2960609774 cites W2223954825 @default.
• W2960609774 cites W2331422587 @default.
• W2960609774 cites W2345127954 @default.
• W2960609774 cites W2388009875 @default.
• W2960609774 cites W2466620019 @default.
• W2960609774 cites W2523744956 @default.
• W2960609774 cites W2579811554 @default.
• W2960609774 cites W2606576211 @default.
• W2960609774 cites W2751911374 @default.
• W2960609774 cites W2752416314 @default.
• W2960609774 cites W2892268520 @default.
• W2960609774 cites W2910682218 @default.
• W2960609774 cites W2921372552 @default.
• W2960609774 cites W2941096646 @default.
• W2960609774 cites W4246359729 @default.
• W2960609774 cites W880586483 @default.
• W2960609774 doi "https://doi.org/10.1016/j.jchromb.2019.121716" @default.
• W2960609774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31319286" @default.
• W2960609774 hasPublicationYear "2019" @default.
• W2960609774 type Work @default.
• W2960609774 sameAs 2960609774 @default.
• W2960609774 citedByCount "7" @default.
• W2960609774 countsByYear W29606097742020 @default.
• W2960609774 countsByYear W29606097742022 @default.
• W2960609774 countsByYear W29606097742023 @default.
• W2960609774 crossrefType "journal-article" @default.
• W2960609774 hasAuthorship W2960609774A5050152496 @default.
• W2960609774 hasAuthorship W2960609774A5066989187 @default.
• W2960609774 hasAuthorship W2960609774A5079553213 @default.
• W2960609774 hasAuthorship W2960609774A5082557734 @default.
• W2960609774 hasAuthorship W2960609774A5088214603 @default.
• W2960609774 hasConcept C10138342 @default.
• W2960609774 hasConcept C11268172 @default.
• W2960609774 hasConcept C112705442 @default.
• W2960609774 hasConcept C126322002 @default.
• W2960609774 hasConcept C15920480 @default.
• W2960609774 hasConcept C162324750 @default.
• W2960609774 hasConcept C162356407 @default.
• W2960609774 hasConcept C178790620 @default.
• W2960609774 hasConcept C179998833 @default.
• W2960609774 hasConcept C184651966 @default.
• W2960609774 hasConcept C185592680 @default.
• W2960609774 hasConcept C21951064 @default.
• W2960609774 hasConcept C2777516009 @default.
• W2960609774 hasConcept C31827203 @default.
• W2960609774 hasConcept C43617362 @default.
• W2960609774 hasConcept C521977710 @default.
• W2960609774 hasConcept C54400483 @default.
• W2960609774 hasConcept C67407626 @default.
• W2960609774 hasConcept C71924100 @default.
• W2960609774 hasConceptScore W2960609774C10138342 @default.
• W2960609774 hasConceptScore W2960609774C11268172 @default.
• W2960609774 hasConceptScore W2960609774C112705442 @default.
• W2960609774 hasConceptScore W2960609774C126322002 @default.
• W2960609774 hasConceptScore W2960609774C15920480 @default.
• W2960609774 hasConceptScore W2960609774C162324750 @default.
• W2960609774 hasConceptScore W2960609774C162356407 @default.
• W2960609774 hasConceptScore W2960609774C178790620 @default.
• W2960609774 hasConceptScore W2960609774C179998833 @default.
• W2960609774 hasConceptScore W2960609774C184651966 @default.
• W2960609774 hasConceptScore W2960609774C185592680 @default.
• W2960609774 hasConceptScore W2960609774C21951064 @default.
• W2960609774 hasConceptScore W2960609774C2777516009 @default.
• W2960609774 hasConceptScore W2960609774C31827203 @default.
• W2960609774 hasConceptScore W2960609774C43617362 @default.
• W2960609774 hasConceptScore W2960609774C521977710 @default.
• W2960609774 hasConceptScore W2960609774C54400483 @default.
• W2960609774 hasConceptScore W2960609774C67407626 @default.
• W2960609774 hasConceptScore W2960609774C71924100 @default.
• W2960609774 hasFunder F4320321001 @default.
• W2960609774 hasFunder F4320335787 @default.
• W2960609774 hasFunder F4320335953 @default.
• W2960609774 hasLocation W29606097741 @default.
• W2960609774 hasLocation W29606097742 @default.
• W2960609774 hasOpenAccess W2960609774 @default.
• W2960609774 hasPrimaryLocation W29606097741 @default.
• W2960609774 hasRelatedWork W1984896027 @default.
• W2960609774 hasRelatedWork W2030420643 @default.
• W2960609774 hasRelatedWork W2042513326 @default.

• next