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• W2960642824 endingPage "1986" @default.
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• W2960642824 abstract "Two common polymorphisms of the peroxisome proliferator-activated receptor gamma (PPARG) gene, rs1801282 and rs3856806, may be important candidate gene loci affecting the susceptibility to ischemic stroke. This case-control study sought to identify the relationship between these two single-nucleotide polymorphisms and ischemic stroke risk in a northern Chinese Han population. A total of 910 ischemic stroke participants were recruited from the First Hospital of China Medical University, Shenyang, China as a case group, of whom 895 completed the study. The 883 healthy controls were recruited from the Health Check Center of the First Hospital of China Medical University, Shenyang, China. All participants or family members provided informed consent. The study protocol was approved by the Ethics Committee of the First Hospital of China Medical University, China on February 20, 2012 (approval No. 2012-38-1). The protocol was registered with the Chinese Clinical Trial Registry (registration number: ChiCTR-COC-17013559). Plasma genomic DNA was extracted from all participants and analyzed for rs1801282 and rs3856806 single nucleotide polymorphisms using a SNaPshot Multiplex sequencing assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression to estimate the association between ischemic stroke and a particular genotype. Results demonstrated that the G allele frequency of the PPARG gene rs1801282 locus was significantly higher in the case group than in the control group (P < 0.001). Individuals carrying the G allele had a 1.844 fold increased risk of ischemic stroke (OR = 1.844, 95% CI: 1.286–2.645, P < 0.001). Individuals carrying the rs3856806 T allele had a 1.366 fold increased risk of ischemic stroke (OR = 1.366, 95% CI: 1.077–1.733, P = 0.010). The distribution frequencies of the PPARG gene haplotypes rs1801282-rs3856806 in the control and case groups were determined. The frequency of distribution in the G-T haplotype case group was significantly higher than that in the control group. The risk of ischemic stroke increased to 2.953 times in individuals carrying the G-T haplotype (OR = 2.953, 95% CI: 2.082–4.190, P < 0.001). The rs1801282 G allele and rs3856806 T allele had a multiplicative interaction (OR = 3.404, 95% CI: 1.631–7.102, P < 0.001) and additive interaction (RERI = 41.705, 95% CI: 14.586–68.824, AP = 0.860; 95% CI: 0.779–0.940; S = 8.170, 95% CI: 3.772–17.697) on ischemic stroke risk, showing a synergistic effect. Of all ischemic stroke cases, 86% were attributed to the interaction of the G allele of rs1801282 and the T allele of rs3856806. The effect of the PPARG rs1801282 G allele on ischemic stroke risk was enhanced in the presence of the rs3856806 T allele (OR = 8.001 vs. 1.844). The effect of the rs3856806 T allele on ischemic stroke risk was also enhanced in the presence of the rs1801282 G allele (OR = 2.546 vs. 1.366). Our results confirmed that the G allele of the PPARG gene rs1801282 locus and the T allele of the rs3856806 locus may be independent risk factors for ischemic stroke in the Han population of northern China, with a synergistic effect between the two alleles." @default.
• W2960642824 created "2019-07-23" @default.
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• W2960642824 date "2019-01-01" @default.
• W2960642824 modified "2023-10-09" @default.
• W2960642824 title "Association between PPARG genetic polymorphisms and ischemic stroke risk in a northern Chinese Han population: a case-control study" @default.
• W2960642824 cites W1485161311 @default.
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• W2960642824 cites W1972579642 @default.
• W2960642824 cites W1976805758 @default.
• W2960642824 cites W1980175560 @default.
• W2960642824 cites W1980263659 @default.
• W2960642824 cites W1996612805 @default.
• W2960642824 cites W1999575197 @default.
• W2960642824 cites W2027363457 @default.
• W2960642824 cites W2030447006 @default.
• W2960642824 cites W2031875266 @default.
• W2960642824 cites W2036302172 @default.
• W2960642824 cites W2039679069 @default.
• W2960642824 cites W2042694949 @default.
• W2960642824 cites W2046997607 @default.
• W2960642824 cites W2051656202 @default.
• W2960642824 cites W2053405913 @default.
• W2960642824 cites W2061793689 @default.
• W2960642824 cites W2070082005 @default.
• W2960642824 cites W2079209433 @default.
• W2960642824 cites W2090713084 @default.
• W2960642824 cites W2098591088 @default.
• W2960642824 cites W2104592369 @default.
• W2960642824 cites W2111223640 @default.
• W2960642824 cites W2111563411 @default.
• W2960642824 cites W2117347334 @default.
• W2960642824 cites W2133214617 @default.
• W2960642824 cites W2134066282 @default.
• W2960642824 cites W2142995800 @default.
• W2960642824 cites W2144678079 @default.
• W2960642824 cites W2147328205 @default.
• W2960642824 cites W2149723686 @default.
• W2960642824 cites W2151776178 @default.
• W2960642824 cites W2153664287 @default.
• W2960642824 cites W2156951682 @default.
• W2960642824 cites W2159133895 @default.
• W2960642824 cites W2166946312 @default.
• W2960642824 cites W2170383324 @default.
• W2960642824 cites W2177727633 @default.
• W2960642824 cites W2205988876 @default.
• W2960642824 cites W2303043072 @default.
• W2960642824 cites W2316774419 @default.
• W2960642824 cites W2317804758 @default.
• W2960642824 cites W2329242915 @default.
• W2960642824 cites W2342338475 @default.
• W2960642824 cites W2397867665 @default.
• W2960642824 cites W2413790285 @default.
• W2960642824 cites W2434669812 @default.
• W2960642824 cites W2469294504 @default.
• W2960642824 cites W2527660462 @default.
• W2960642824 cites W2569387348 @default.
• W2960642824 cites W2572496857 @default.
• W2960642824 cites W2598825811 @default.
• W2960642824 cites W2626428549 @default.
• W2960642824 cites W2648859155 @default.
• W2960642824 cites W2765294066 @default.
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• W2960642824 doi "https://doi.org/10.4103/1673-5374.259621" @default.
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