Matches in SemOpenAlex for { <https://semopenalex.org/work/W2960666426> ?p ?o ?g. }
- W2960666426 endingPage "4763" @default.
- W2960666426 startingPage "4750" @default.
- W2960666426 abstract "Hydroxyapatite (HAP) is the major biomineral of bone. Despite the large number of studies addressing HAP formation, a fundamental understanding of the critical roles of HAP-forming proteins in vitro is needed. Effects of two HAP-interacting proteins, osteocalcin (OCN) and osteopontin (OPN), on HAP formation was investigated via in vitro biomineralization experiments, and their outcomes on the crystal structure of calcium phosphate (CaP) was revealed. Our data suggest that OCN concentration is negatively correlated with crystal formation rate and crystal size, yet the presence of OCN leads to a more ordered HAP crystal formation. On the other hand, OPN protein promotes faster formation of CaP crystals potentially working as a growth site for mineral formation, and it decreases the Ca:P ratio. This effect results in a shift from HAP-type minerals to less ordered crystals. The crystal size, shape, and Ca:P ratio can be tuned to design improved mammalian hard tissue environment-mimicking matrices by taking advantage of the OCN and OPN proteins on crystal formation. We believe our current findings will lead to innovative approaches for bone biomineralization in regenerative medicine." @default.
- W2960666426 created "2019-07-23" @default.
- W2960666426 creator A5017428126 @default.
- W2960666426 creator A5017450743 @default.
- W2960666426 creator A5027204509 @default.
- W2960666426 creator A5045933903 @default.
- W2960666426 creator A5071444535 @default.
- W2960666426 date "2019-07-09" @default.
- W2960666426 modified "2023-10-16" @default.
- W2960666426 title "Biomineralization of Calcium Phosphate Crystals Controlled by Protein–Protein Interactions" @default.
- W2960666426 cites W1505588480 @default.
- W2960666426 cites W1534534898 @default.
- W2960666426 cites W1551461802 @default.
- W2960666426 cites W1588979652 @default.
- W2960666426 cites W1869516088 @default.
- W2960666426 cites W1912515756 @default.
- W2960666426 cites W1939160658 @default.
- W2960666426 cites W1939982746 @default.
- W2960666426 cites W1965981687 @default.
- W2960666426 cites W1969750812 @default.
- W2960666426 cites W1971163872 @default.
- W2960666426 cites W1971439989 @default.
- W2960666426 cites W1971877746 @default.
- W2960666426 cites W1984783294 @default.
- W2960666426 cites W1987500038 @default.
- W2960666426 cites W1992054371 @default.
- W2960666426 cites W1996223704 @default.
- W2960666426 cites W2000231256 @default.
- W2960666426 cites W2013496911 @default.
- W2960666426 cites W2014097308 @default.
- W2960666426 cites W2014971588 @default.
- W2960666426 cites W2017526934 @default.
- W2960666426 cites W2018557551 @default.
- W2960666426 cites W2024394228 @default.
- W2960666426 cites W2024978791 @default.
- W2960666426 cites W2028421282 @default.
- W2960666426 cites W2028660381 @default.
- W2960666426 cites W2033740098 @default.
- W2960666426 cites W2035944449 @default.
- W2960666426 cites W2038980060 @default.
- W2960666426 cites W2041595300 @default.
- W2960666426 cites W2042450103 @default.
- W2960666426 cites W2043103956 @default.
- W2960666426 cites W2046493202 @default.
- W2960666426 cites W2052749920 @default.
- W2960666426 cites W2055322436 @default.
- W2960666426 cites W2058204865 @default.
- W2960666426 cites W2058268622 @default.
- W2960666426 cites W2060179084 @default.
- W2960666426 cites W2063034608 @default.
- W2960666426 cites W2066052326 @default.
- W2960666426 cites W2069110136 @default.
- W2960666426 cites W2069494032 @default.
- W2960666426 cites W2072842144 @default.
- W2960666426 cites W2082266074 @default.
- W2960666426 cites W2083458940 @default.
- W2960666426 cites W2088972187 @default.
- W2960666426 cites W2089264492 @default.
- W2960666426 cites W2103733715 @default.
- W2960666426 cites W2114528551 @default.
- W2960666426 cites W2125538936 @default.
- W2960666426 cites W2129653665 @default.
- W2960666426 cites W2133819222 @default.
- W2960666426 cites W2139377231 @default.
- W2960666426 cites W2141502046 @default.
- W2960666426 cites W2142962510 @default.
- W2960666426 cites W2158687094 @default.
- W2960666426 cites W2166179228 @default.
- W2960666426 cites W2169243554 @default.
- W2960666426 cites W2199338994 @default.
- W2960666426 cites W2200416927 @default.
- W2960666426 cites W2232407802 @default.
- W2960666426 cites W2329880895 @default.
- W2960666426 cites W2552642179 @default.
- W2960666426 cites W2564512014 @default.
- W2960666426 cites W2578851460 @default.
- W2960666426 cites W2586072400 @default.
- W2960666426 cites W2737735897 @default.
- W2960666426 cites W2794319682 @default.
- W2960666426 cites W4211142228 @default.
- W2960666426 cites W4252543199 @default.
- W2960666426 doi "https://doi.org/10.1021/acsbiomaterials.9b00649" @default.
- W2960666426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33448818" @default.
- W2960666426 hasPublicationYear "2019" @default.
- W2960666426 type Work @default.
- W2960666426 sameAs 2960666426 @default.
- W2960666426 citedByCount "13" @default.
- W2960666426 countsByYear W29606664262020 @default.
- W2960666426 countsByYear W29606664262021 @default.
- W2960666426 countsByYear W29606664262022 @default.
- W2960666426 countsByYear W29606664262023 @default.
- W2960666426 crossrefType "journal-article" @default.
- W2960666426 hasAuthorship W2960666426A5017428126 @default.
- W2960666426 hasAuthorship W2960666426A5017450743 @default.
- W2960666426 hasAuthorship W2960666426A5027204509 @default.
- W2960666426 hasAuthorship W2960666426A5045933903 @default.
- W2960666426 hasAuthorship W2960666426A5071444535 @default.
- W2960666426 hasBestOaLocation W29606664262 @default.