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- W2960674259 endingPage "719" @default.
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- W2960674259 abstract "Abstract Homocysteine [HSCH 2 CH 2 CH(NH 2 )COOH] (Hcy) is a sulfur‐containing amino acid of 135.18 Da of molecular weight, generated during conversion of methionine to cysteine. If there is a higher accumulation of Hcy in the blood, that is usually above 15 µmol/L, it leads to a condition referred to as hyperhomocysteinemia. A meta‐analysis of observational study suggested an elevated concentration of Hcy in blood, which is termed as the risk factors leading to ischemic heart disease and stroke. Further experimental studies stated that Hcy can lead to an increase in the proliferation of vascular smooth muscle cells and functional impairment of endothelial cells. The analyses confirmed some of the predictors for Hcy presence, such as serum uric acid (UA), systolic blood pressure, and hematocrit. However, angiotensin‐converting enzyme inhibitors angiotensin‐converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) alone are inadequate for controlling UA and creatinine level, although the addition of folic acid may be beneficial in hypertensive patients who are known to have a high prevalence of elevated Hcy. We hypothesized that combination therapy with an ARB (olmesartan) and folic acid is a promising treatment for lowering the UA and creatinine level in hyperhomocysteinemia‐associated hypertension." @default.
- W2960674259 created "2019-07-23" @default.
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- W2960674259 date "2019-07-26" @default.
- W2960674259 modified "2023-09-26" @default.
- W2960674259 title "Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia‐associated hypertension" @default.
- W2960674259 cites W1490545395 @default.
- W2960674259 cites W1757751439 @default.
- W2960674259 cites W1968584268 @default.
- W2960674259 cites W1974562980 @default.
- W2960674259 cites W1975403468 @default.
- W2960674259 cites W1977841860 @default.
- W2960674259 cites W1978998408 @default.
- W2960674259 cites W1981080170 @default.
- W2960674259 cites W1981880904 @default.
- W2960674259 cites W1984782606 @default.
- W2960674259 cites W1988817734 @default.
- W2960674259 cites W1997103981 @default.
- W2960674259 cites W2001253024 @default.
- W2960674259 cites W2005468240 @default.
- W2960674259 cites W2008240978 @default.
- W2960674259 cites W2012550132 @default.
- W2960674259 cites W2014793094 @default.
- W2960674259 cites W2023714087 @default.
- W2960674259 cites W2030117384 @default.
- W2960674259 cites W2031005241 @default.
- W2960674259 cites W2033958794 @default.
- W2960674259 cites W2036163062 @default.
- W2960674259 cites W2041220232 @default.
- W2960674259 cites W2053095897 @default.
- W2960674259 cites W2054965061 @default.
- W2960674259 cites W2056007625 @default.
- W2960674259 cites W2057469776 @default.
- W2960674259 cites W2064868021 @default.
- W2960674259 cites W2069737223 @default.
- W2960674259 cites W2072528042 @default.
- W2960674259 cites W2074768230 @default.
- W2960674259 cites W2075505106 @default.
- W2960674259 cites W2078370240 @default.
- W2960674259 cites W2081141992 @default.
- W2960674259 cites W20853968 @default.
- W2960674259 cites W2086773144 @default.
- W2960674259 cites W2087355759 @default.
- W2960674259 cites W2087840572 @default.
- W2960674259 cites W2093110099 @default.
- W2960674259 cites W2103085707 @default.
- W2960674259 cites W2107123016 @default.
- W2960674259 cites W2113103899 @default.
- W2960674259 cites W2117413045 @default.
- W2960674259 cites W2118626367 @default.
- W2960674259 cites W2118768784 @default.
- W2960674259 cites W2119226590 @default.
- W2960674259 cites W2122142898 @default.
- W2960674259 cites W2126125759 @default.
- W2960674259 cites W2135138745 @default.
- W2960674259 cites W2137214955 @default.
- W2960674259 cites W2140132180 @default.
- W2960674259 cites W2148698885 @default.
- W2960674259 cites W2159058075 @default.
- W2960674259 cites W2163239673 @default.
- W2960674259 cites W2163856132 @default.
- W2960674259 cites W2170912509 @default.
- W2960674259 cites W2230430502 @default.
- W2960674259 cites W2327576448 @default.
- W2960674259 cites W2340007607 @default.
- W2960674259 cites W2409436541 @default.
- W2960674259 cites W2524575458 @default.
- W2960674259 cites W2549991915 @default.
- W2960674259 cites W2558026802 @default.
- W2960674259 cites W2592164257 @default.
- W2960674259 cites W2593325807 @default.
- W2960674259 cites W2604915808 @default.
- W2960674259 cites W2606844783 @default.
- W2960674259 cites W2615266819 @default.
- W2960674259 cites W2753871913 @default.
- W2960674259 cites W2769862189 @default.
- W2960674259 cites W2780027234 @default.
- W2960674259 cites W2784302352 @default.
- W2960674259 cites W2791159319 @default.
- W2960674259 cites W2799972478 @default.
- W2960674259 cites W2802355956 @default.
- W2960674259 cites W2802647110 @default.
- W2960674259 cites W2804125783 @default.
- W2960674259 cites W2806561423 @default.
- W2960674259 cites W2888961376 @default.
- W2960674259 cites W2896915795 @default.
- W2960674259 cites W2936031459 @default.