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• W2960690799 abstract "The imprinted delta like 1 homolog ( DLK1 ) - thyroxine deiodinase type III ( DIO3 ) locus regulates development and growth. Its imprinting regulation involves two differentially methylated regions (DMRs), intergenic-DMR (IG-DMR) and maternally expressed gene 3-DMR (Meg3-DMR). In mice, a maternal deletion of the IG-DMR leads to LOI in the locus, proving that the IG-DMR is a cis-acting imprinting control region of the locus. However, the Meg3-DMR overlaps with the promoter, exon 1 and intron 1 of the Meg3 gene. Because deletion of the Meg3-DMR inactivates the Meg3 gene, their roles in imprinting regulation of Meg3-DMR mice is unknown. Therefore, we generated two mouse models: Meg3 Δ(1-4) and Meg3 Δ(2-4) , respectively targeting exons 1–4 and exons 2–4 of the Meg3 gene. A maternal deletion of Meg3 Δ(1-4) caused embryonic death and LOI in both embryos and placentas, but did not affect methylation status of the IG-DMR. In contrast, mice carrying a maternal deletion of Meg3 Δ(2-4) were born normally and did not have LOI. These data indicate that it is the Meg3-DMR, not the Meg3 gene, which regulates imprinting of the Dlk1-Dio3 locus. • Deletion of Meg3 exons 1–4, overlapping the Meg3-DMR, results in loss of imprinting. • Deletion of Meg3 exons 2–4, downstream of the Meg3-DMR, does not affect imprinting. • Meg3-DMR, not the Meg3 gene, regulates imprinting of the Dlk1-Dio3 locus." @default.
• W2960690799 created "2019-07-23" @default.
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• W2960690799 date "2019-11-01" @default.
• W2960690799 modified "2023-09-24" @default.
• W2960690799 title "Meg3-DMR, not the Meg3 gene, regulates imprinting of the Dlk1-Dio3 locus" @default.
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• W2960690799 doi "https://doi.org/10.1016/j.ydbio.2019.07.005" @default.
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