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- W2960692223 abstract "The importance of axial chirality in enantioselective synthesis has been widely recognized for decades. The practical access to certain structures such as biaryl amino phenols known as NOBINs in enantiopure form, however, still remains a challenge. In drug delivery, the incorporation of axially chiral molecules in systematic screening has also received a great deal of interest in recent years, which calls for innovation and practical synthesis of structurally different axially chiral entities. Herein we present an operationally simple catalytic N-alkylation of sulfonamides using commercially available chiral amine catalysts to deliver two important classes of axially chiral compounds: structurally diverse NOBIN analogs as well as axially chiral N-aryl sulfonamides in excellent enantiopurity. Structurally related chiral sulfonamide has shown great potential in drug molecules but enantioselective synthesis of them has never been accomplished before. The practical catalytic procedures of our methods also bode well for their wide application in enantioselective synthesis." @default.
- W2960692223 created "2019-07-23" @default.
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- W2960692223 date "2019-07-11" @default.
- W2960692223 modified "2023-10-13" @default.
- W2960692223 title "Practical access to axially chiral sulfonamides and biaryl amino phenols via organocatalytic atroposelective N-alkylation" @default.
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- W2960692223 doi "https://doi.org/10.1038/s41467-019-10940-4" @default.
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