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- W296074847 abstract "The clinical course of chronic hepatitis C virus (HCV) infection is characterized by possible development of both liver and extrahepatic disorders. The tropism of HCV for the lymphoid tissue is responsible for several immune-mediated disorders; a poly-oligoclonal B-lymphocyte expansion, commonly observed in a high proportion of patients with HCV infection, are responsible for the production of different autoantibodies and immune-complexes, such as mixed cryoglobulins. These serological alterations may characterize a variety of autoimmune or neoplastic diseases. Cryoglobulinemic vasculitis due to small-vessel deposition of circulating mixed cryoglobulins is the prototype of HCV-driven immune-mediated and lymphoproliferative disorders; interestingly, in some cases the disease may evolve to frank malignant lymphoma. In addition, HCV shows an oncogenic potential as suggested by several clinico-epidemiological and laboratory studies; in addition to hepatocellular carcinoma that represents the most frequent HCV-related malignancy, a causative role of HCV has been largely demonstrated in a significant percentage of patients with isolated B-cells non-Hodgkin's lymphomas. The same virus may be also involved in the pathogenesis of papillary thyroid cancer, a rare neoplastic condition that may complicate HCV-related thyroid involvement. Patients with HCV infection are frequently asymptomatic or may develop only hepatic alteration, while a limited but clinically relevant number can develop one or more autoimmune and/or neoplastic disorders. Given the large variability of their prevalence among patients' populations from different countries, it is possible to hypothesize a potential role of other co-factors, i.e., genetic and/or environmental, in the pathogenesis of HCV-related extra-hepatic diseases." @default.
- W296074847 created "2016-06-24" @default.
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- W296074847 date "2015-01-01" @default.
- W296074847 modified "2023-10-14" @default.
- W296074847 title "HCV syndrome: A constellation of organ- and non-organ specific autoimmune disorders, B-cell non-Hodgkin’s lymphoma, and cancer" @default.
- W296074847 cites W106318866 @default.
- W296074847 cites W1594734615 @default.
- W296074847 cites W1597286596 @default.
- W296074847 cites W1624220686 @default.
- W296074847 cites W1778438381 @default.
- W296074847 cites W1811170696 @default.
- W296074847 cites W1963920328 @default.
- W296074847 cites W1966884256 @default.
- W296074847 cites W1966887492 @default.
- W296074847 cites W1968260895 @default.
- W296074847 cites W1969338599 @default.
- W296074847 cites W1970450296 @default.
- W296074847 cites W1973327380 @default.
- W296074847 cites W1974604854 @default.
- W296074847 cites W1975963101 @default.
- W296074847 cites W1979913015 @default.
- W296074847 cites W1981190826 @default.
- W296074847 cites W1982644308 @default.
- W296074847 cites W1983621878 @default.
- W296074847 cites W1984353465 @default.
- W296074847 cites W1986416046 @default.
- W296074847 cites W1991420086 @default.
- W296074847 cites W1994716504 @default.
- W296074847 cites W1998845009 @default.
- W296074847 cites W2001679455 @default.
- W296074847 cites W2002828328 @default.
- W296074847 cites W2003036666 @default.
- W296074847 cites W2004640968 @default.
- W296074847 cites W2004690964 @default.
- W296074847 cites W2006309458 @default.
- W296074847 cites W2006585940 @default.
- W296074847 cites W2007973442 @default.
- W296074847 cites W2011345683 @default.
- W296074847 cites W2013864081 @default.
- W296074847 cites W2015641526 @default.
- W296074847 cites W2015686782 @default.
- W296074847 cites W2018115298 @default.
- W296074847 cites W2019985783 @default.
- W296074847 cites W2022687771 @default.
- W296074847 cites W2024190714 @default.
- W296074847 cites W2028448084 @default.
- W296074847 cites W2030615083 @default.
- W296074847 cites W2031406654 @default.
- W296074847 cites W203157681 @default.
- W296074847 cites W2032043967 @default.
- W296074847 cites W2032370956 @default.
- W296074847 cites W2032628333 @default.
- W296074847 cites W2035331745 @default.
- W296074847 cites W2036111541 @default.
- W296074847 cites W2037339647 @default.
- W296074847 cites W2038933712 @default.
- W296074847 cites W2039490086 @default.
- W296074847 cites W2041435542 @default.
- W296074847 cites W2042761836 @default.
- W296074847 cites W2043347593 @default.
- W296074847 cites W2051596205 @default.
- W296074847 cites W2053326488 @default.
- W296074847 cites W2056788149 @default.
- W296074847 cites W2060024172 @default.
- W296074847 cites W2060523549 @default.
- W296074847 cites W2064967094 @default.
- W296074847 cites W2066195270 @default.
- W296074847 cites W2073481601 @default.
- W296074847 cites W2075223865 @default.
- W296074847 cites W2075347828 @default.
- W296074847 cites W2076800268 @default.
- W296074847 cites W2077515082 @default.
- W296074847 cites W2079152838 @default.
- W296074847 cites W2081540010 @default.
- W296074847 cites W2083699867 @default.
- W296074847 cites W2083883069 @default.
- W296074847 cites W2084897447 @default.
- W296074847 cites W2085841456 @default.
- W296074847 cites W2086548050 @default.
- W296074847 cites W2087164555 @default.
- W296074847 cites W2089473659 @default.
- W296074847 cites W2089723589 @default.
- W296074847 cites W2090887217 @default.
- W296074847 cites W2093326386 @default.
- W296074847 cites W2093933802 @default.
- W296074847 cites W2094143424 @default.
- W296074847 cites W2099665302 @default.
- W296074847 cites W2101942207 @default.
- W296074847 cites W2103449318 @default.
- W296074847 cites W2104507861 @default.