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• W2960760892 abstract "Abstract Searching for vaccines (antigen and adjuvant) with easy preparation and strong T‐cell response are crucial for antitumor immunity. In this work, to design lymphoseek‐inspired vaccine possessing the abilities of promoting vaccine internalization and enhancing CD8 + T‐cell responses, a simple multicomponent strategy is successfully utilized to fabricate lymph node and dendritic cell dual‐targeting glycoadjuvant@AuNPs in one pot, where three different components, catechol‐containing glycopolymer, HAuCl 4 , and amine‐terminal CpG (CpG‐NH 2 ) can react in a single step to generate target adjuvant. It is found that hetero‐glycoadjuvant@AuNPs could increase adjuvant internalization and enhance the activation of bone‐marrow‐derived dendritic cells. Critically, lymphoseek‐inspired vaccine potentiates antigen‐specific CD8 + T‐cell immune responses." @default.
• W2960760892 created "2019-07-23" @default.
• W2960760892 creator A5030054664 @default.
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• W2960760892 date "2019-07-11" @default.
• W2960760892 modified "2023-10-14" @default.
• W2960760892 title "One‐Pot, Multicomponent Strategy for Designing Lymphoseek‐Inspired Hetero‐Glycoadjuvant@AuNPs" @default.
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• W2960760892 doi "https://doi.org/10.1002/marc.201900215" @default.
• W2960760892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31294497" @default.
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