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- W2960776656 endingPage "577006" @default.
- W2960776656 startingPage "577006" @default.
- W2960776656 abstract "Viruses that invade the central nervous system (CNS) can cause neuropsychiatric impairments. Similarly, chronic alcohol exposure can induce inflammatory responses that alter brain function. However, the effects of a chronic viral infection and comorbid alcohol use on neuroinflammation and behavior are not well-defined. We investigated the role of heavy alcohol intake in regulating inflammatory responses and behavioral signs of cognitive impairments in mice infected with lymphocytic choriomeningitis virus (LCMV) clone 13. LCMV-infected mice exposed to alcohol had increased peripheral inflammation and impaired cognitive function (as indicated by performance on the novel object recognition test). Initial findings suggest that brain region-specific dysregulation of microglial response to viral infection may contribute to cognitive impairments in the context of heavy alcohol use." @default.
- W2960776656 created "2019-07-23" @default.
- W2960776656 creator A5044934919 @default.
- W2960776656 creator A5045868100 @default.
- W2960776656 creator A5062261333 @default.
- W2960776656 creator A5073950799 @default.
- W2960776656 date "2019-10-01" @default.
- W2960776656 modified "2023-09-27" @default.
- W2960776656 title "Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection: An initial investigation" @default.
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