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- W2960917400 abstract "ABSTRACT While recent studies have uncovered dedicated neural pathways mediating the positive control of parenting, the regulation of infant-directed aggression and how it relates to adult-adult aggression is poorly understood. Here we show that urocortin-3 ( Ucn3 )-expressing neurons in the hypothalamic perifornical area (PeFA Ucn3 ) are activated during infant-directed attacks in males and females, but not other behaviors. Functional manipulations of PeFA Ucn3 neurons demonstrate the role of this population in the negative control of parenting in both sexes. PeFA Ucn3 neurons receive input from areas associated with vomeronasal sensing, stress, and parenting, and send projections to hypothalamic and limbic areas. Optogenetic activation of PeFA Ucn3 axon terminals in these regions triggers various aspects of infant-directed agonistic responses, such as neglect, repulsion and aggression. Thus, PeFA Ucn3 neurons emerge as a dedicated circuit component controlling infant-directed neglect and aggression, providing a new framework to understand the positive and negative regulation of parenting in health and disease." @default.
- W2960917400 created "2019-07-23" @default.
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- W2960917400 date "2019-07-09" @default.
- W2960917400 modified "2023-09-23" @default.
- W2960917400 title "Urocortin-3 Neurons in the Mouse Perifornical Area Promote Infant-directed Neglect and Aggression" @default.
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- W2960917400 doi "https://doi.org/10.1101/697334" @default.
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