FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2960949643> ?p ?o ?g. }

• W2960949643 abstract "Abstract As we reported in our previous studies, TMTP1, a tumor-homing peptide, selectively targets highly metastatic tumors and their metastatic foci. Aminopeptidase P2 (XPNPEP2) is a receptor for TMTP1 tumor-homing peptide. However, the biological and clinical significance of Aminopeptidase P2 in human cancers remains unknown. In this study, the high-density multiple organ tumor tissue array was employed for the analysis of XPNPEP2 expression profiles in human specimens. The results showed that XPNPEP2 was moderately expressed in the normal prostate tissues, but significantly decreased in the prostate cancer. Hence we used TCGA, IHC, and ELISA to further analyze the expression of XPNPEP2 in tissues and serum of prostate cancer patients. In general, XPNPEP2 expression was lower in prostate cancer tissue than in normal prostate tissue, but was higher in prostate cancer tissues with local invasion and LN metastasis than in tissues with localized Pca. Western blot clarified XPNPEP2 had a secreted form in the serum. Then the serums of 128 Pca patients, 70 healthy males and 40 prostate hyperplasia patients were obtained for detecting serum XPNPEP2 levels.The results indicated that the concentration of XPNPEP2 in serums of Pca patients with LN metastasis (142.7 ± 14.40 ng/mL) were significantly higher than levels in Pca patients without LN metastasis (61.63 ± 5.50 ng/mL) ( p < 0.01). An ROC analysis revealed that the combination of PSA and XPNPEP2 was more efficient than PSA or XPNPEP2 alone for predicting LN metastasis, especially for Pca patients with low serum PSA levels. In summary, serum XPNPEP2 levels when combined with PSA levels may result in increased sensitivity for predicting LN metastasis in Pca patients, especially for patients with low serum PSA levels." @default.
• W2960949643 created "2019-07-23" @default.
• W2960949643 creator A5005228021 @default.
• W2960949643 creator A5005446988 @default.
• W2960949643 creator A5016030980 @default.
• W2960949643 creator A5026746035 @default.
• W2960949643 creator A5029125895 @default.
• W2960949643 creator A5035199886 @default.
• W2960949643 creator A5046274878 @default.
• W2960949643 creator A5052590910 @default.
• W2960949643 creator A5073143493 @default.
• W2960949643 date "2019-07-11" @default.
• W2960949643 modified "2023-10-18" @default.
• W2960949643 title "XPNPEP2 is associated with lymph node metastasis in prostate cancer patients" @default.
• W2960949643 cites W1486646743 @default.
• W2960949643 cites W1770846351 @default.
• W2960949643 cites W1957395002 @default.
• W2960949643 cites W1973457222 @default.
• W2960949643 cites W1990884813 @default.
• W2960949643 cites W2032790499 @default.
• W2960949643 cites W2038331078 @default.
• W2960949643 cites W2059270301 @default.
• W2960949643 cites W2080928007 @default.
• W2960949643 cites W2087280807 @default.
• W2960949643 cites W2099836603 @default.
• W2960949643 cites W2109900423 @default.
• W2960949643 cites W2114843025 @default.
• W2960949643 cites W2130853322 @default.
• W2960949643 cites W2133299910 @default.
• W2960949643 cites W2141319262 @default.
• W2960949643 cites W2142395600 @default.
• W2960949643 cites W2148070136 @default.
• W2960949643 cites W2149441684 @default.
• W2960949643 cites W2292939892 @default.
• W2960949643 cites W2327870143 @default.
• W2960949643 cites W2343731960 @default.
• W2960949643 cites W2607129810 @default.
• W2960949643 cites W2735466241 @default.
• W2960949643 cites W2902301698 @default.
• W2960949643 cites W4320300902 @default.
• W2960949643 doi "https://doi.org/10.1038/s41598-019-45245-5" @default.
• W2960949643 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6624198" @default.
• W2960949643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31296901" @default.
• W2960949643 hasPublicationYear "2019" @default.
• W2960949643 type Work @default.
• W2960949643 sameAs 2960949643 @default.
• W2960949643 citedByCount "6" @default.
• W2960949643 countsByYear W29609496432020 @default.
• W2960949643 countsByYear W29609496432021 @default.
• W2960949643 countsByYear W29609496432022 @default.
• W2960949643 crossrefType "journal-article" @default.
• W2960949643 hasAuthorship W2960949643A5005228021 @default.
• W2960949643 hasAuthorship W2960949643A5005446988 @default.
• W2960949643 hasAuthorship W2960949643A5016030980 @default.
• W2960949643 hasAuthorship W2960949643A5026746035 @default.
• W2960949643 hasAuthorship W2960949643A5029125895 @default.
• W2960949643 hasAuthorship W2960949643A5035199886 @default.
• W2960949643 hasAuthorship W2960949643A5046274878 @default.
• W2960949643 hasAuthorship W2960949643A5052590910 @default.
• W2960949643 hasAuthorship W2960949643A5073143493 @default.
• W2960949643 hasBestOaLocation W29609496431 @default.
• W2960949643 hasConcept C121608353 @default.
• W2960949643 hasConcept C126322002 @default.
• W2960949643 hasConcept C142724271 @default.
• W2960949643 hasConcept C143998085 @default.
• W2960949643 hasConcept C151872237 @default.
• W2960949643 hasConcept C18903297 @default.
• W2960949643 hasConcept C204232928 @default.
• W2960949643 hasConcept C2776235491 @default.
• W2960949643 hasConcept C2777562237 @default.
• W2960949643 hasConcept C2779013556 @default.
• W2960949643 hasConcept C2779720271 @default.
• W2960949643 hasConcept C2780192828 @default.
• W2960949643 hasConcept C502942594 @default.
• W2960949643 hasConcept C71924100 @default.
• W2960949643 hasConcept C86803240 @default.
• W2960949643 hasConcept C87874733 @default.
• W2960949643 hasConceptScore W2960949643C121608353 @default.
• W2960949643 hasConceptScore W2960949643C126322002 @default.
• W2960949643 hasConceptScore W2960949643C142724271 @default.
• W2960949643 hasConceptScore W2960949643C143998085 @default.
• W2960949643 hasConceptScore W2960949643C151872237 @default.
• W2960949643 hasConceptScore W2960949643C18903297 @default.
• W2960949643 hasConceptScore W2960949643C204232928 @default.
• W2960949643 hasConceptScore W2960949643C2776235491 @default.
• W2960949643 hasConceptScore W2960949643C2777562237 @default.
• W2960949643 hasConceptScore W2960949643C2779013556 @default.
• W2960949643 hasConceptScore W2960949643C2779720271 @default.
• W2960949643 hasConceptScore W2960949643C2780192828 @default.
• W2960949643 hasConceptScore W2960949643C502942594 @default.
• W2960949643 hasConceptScore W2960949643C71924100 @default.
• W2960949643 hasConceptScore W2960949643C86803240 @default.
• W2960949643 hasConceptScore W2960949643C87874733 @default.
• W2960949643 hasFunder F4320321001 @default.
• W2960949643 hasIssue "1" @default.
• W2960949643 hasLocation W29609496431 @default.
• W2960949643 hasLocation W29609496432 @default.
• W2960949643 hasLocation W29609496433 @default.
• W2960949643 hasOpenAccess W2960949643 @default.
• W2960949643 hasPrimaryLocation W29609496431 @default.

• next