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• W2961001038 abstract "Electrospun nanofibers have been widely studied for many medical applications. They can be designed with specific features, including mucoadhesive properties. This review summarizes the polymeric scaffolds obtained by the electrospinning process that has been applied for drug release in different mucosal sites such as oral, ocular, gastroenteric, vaginal, and nasal. We analyzed the electrospinning parameters that have to be optimized to create reproducible and efficient mucoadhesive nanofibers, among them are: electrical field, polymer concentration, viscosity, flow rate, needle-collector distance, solution conductivity, solvent, environmental parameters, and electrospinning setup. We also revised the mucoadhesive theories as well as the mucoadhesive properties of the polymers used. This review shows that the most studied mucosal site is the oral cavity, because it is accessible and easy to evaluate, while the rest are uncomfortable for the patient and difficult to assess in vivo. We found problems that need to be solved for mucoadhesive electrospun nanofibers, such as improving adhesion strength and mucosal permanence time, and the design of unidirectional release, multilayer systems for the treatment of several pathologies, to ensure the drug concentration in the tissue or target organ." @default.
• W2961001038 created "2019-07-23" @default.
• W2961001038 creator A5018553372 @default.
• W2961001038 creator A5025281863 @default.
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• W2961001038 creator A5036457877 @default.
• W2961001038 creator A5052901951 @default.
• W2961001038 date "2019-07-01" @default.
• W2961001038 modified "2023-10-11" @default.
• W2961001038 title "<p>Mucoadhesive electrospun nanofibers for drug delivery systems: applications of polymers and the parameters’ roles</p>" @default.
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• W2961001038 doi "https://doi.org/10.2147/ijn.s193328" @default.
• W2961001038 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6643962" @default.
• W2961001038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31409989" @default.
• W2961001038 hasPublicationYear "2019" @default.
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