FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2961061133> ?p ?o ?g. }

• W2961061133 endingPage "e0007567" @default.
• W2961061133 startingPage "e0007567" @default.
• W2961061133 abstract "Invasive fungal infections (IFI) is a worldwide serious health problem and Amphotericin B (AmB) has been considered the drug of choice for IFI treatment. Despite its efficacy, clinical use of AmB has been associated with renal toxicity. Some lines of evidence have shown that an extemporaneous lipid emulsion preparation of AmB (AmB/LE) was able to attenuate nephrotoxicity, presenting similar benefits at a lower cost. Studies have been demonstrating that hypovitaminosis D may hasten the progression of kidney disease and reflect on a worse prognosis in cases of drug-induced nephrotoxicity. In view of the high worldwide incidence of hypovitaminosis D, the aim of this study was to investigate whether vitamin D deficiency may induce AmB/LE-related nephrotoxicity. Wistar rats were divided into four groups: control, received a standard diet for 34 days; AmB/LE, received a standard diet for 34 days and AmB/LE (5 mg/kg/day) intraperitoneally in the last 4 days; VDD, received a vitamin D-free diet for 34 days; and VDD+AmB/LE, received a vitamin D-free diet for 34 days and AmB/LE as described. At the end of the protocol, animals were euthanized and blood, urine and renal tissue samples were collected in order to evaluate AmB/LE effects on renal function and morphology. Association of AmB/LE and vitamin D deficiency led to diminished glomerular filtration rate and increased tubular injury, evidenced by reduced renal protein expression of NaPi-IIa and TRPM6 leading to hyperphosphaturia / hypermagnesuria. VDD+AmB/LE rats also presented alterations in the PTH-Klotho-FGF-23 signaling axis, urinary concentrating defect and hypertension, probably due to an inappropriate activation of the renin-angiotensin-aldosterone system. Hence, it is important to monitor vitamin D levels in AmB/LE treated patients, since vitamin D deficiency induces AmB/LE nephrotoxicity." @default.
• W2961061133 created "2019-07-23" @default.
• W2961061133 creator A5016295551 @default.
• W2961061133 creator A5018706308 @default.
• W2961061133 creator A5021307372 @default.
• W2961061133 creator A5033323935 @default.
• W2961061133 creator A5062157046 @default.
• W2961061133 creator A5062357593 @default.
• W2961061133 creator A5079825950 @default.
• W2961061133 creator A5090265444 @default.
• W2961061133 date "2019-07-11" @default.
• W2961061133 modified "2023-10-18" @default.
• W2961061133 title "Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity" @default.
• W2961061133 cites W1965285810 @default.
• W2961061133 cites W1966074338 @default.
• W2961061133 cites W1968199305 @default.
• W2961061133 cites W1972662184 @default.
• W2961061133 cites W1976895119 @default.
• W2961061133 cites W1991149656 @default.
• W2961061133 cites W1994537370 @default.
• W2961061133 cites W2000422963 @default.
• W2961061133 cites W2010964273 @default.
• W2961061133 cites W2032136872 @default.
• W2961061133 cites W2032206735 @default.
• W2961061133 cites W2054122582 @default.
• W2961061133 cites W2068119388 @default.
• W2961061133 cites W2076076557 @default.
• W2961061133 cites W2084458610 @default.
• W2961061133 cites W2084505644 @default.
• W2961061133 cites W2090366040 @default.
• W2961061133 cites W2102390615 @default.
• W2961061133 cites W2106115383 @default.
• W2961061133 cites W2111817213 @default.
• W2961061133 cites W2113139464 @default.
• W2961061133 cites W2114386003 @default.
• W2961061133 cites W2119640039 @default.
• W2961061133 cites W2123037988 @default.
• W2961061133 cites W2127059157 @default.
• W2961061133 cites W2130685053 @default.
• W2961061133 cites W2141255365 @default.
• W2961061133 cites W2141749651 @default.
• W2961061133 cites W2168781246 @default.
• W2961061133 cites W2291785315 @default.
• W2961061133 cites W2397954084 @default.
• W2961061133 cites W2417409022 @default.
• W2961061133 cites W2555924635 @default.
• W2961061133 cites W2897978664 @default.
• W2961061133 cites W3023983541 @default.
• W2961061133 doi "https://doi.org/10.1371/journal.pntd.0007567" @default.
• W2961061133 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6622473" @default.
• W2961061133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31295336" @default.
• W2961061133 hasPublicationYear "2019" @default.
• W2961061133 type Work @default.
• W2961061133 sameAs 2961061133 @default.
• W2961061133 citedByCount "6" @default.
• W2961061133 countsByYear W29610611332021 @default.
• W2961061133 countsByYear W29610611332022 @default.
• W2961061133 countsByYear W29610611332023 @default.
• W2961061133 crossrefType "journal-article" @default.
• W2961061133 hasAuthorship W2961061133A5016295551 @default.
• W2961061133 hasAuthorship W2961061133A5018706308 @default.
• W2961061133 hasAuthorship W2961061133A5021307372 @default.
• W2961061133 hasAuthorship W2961061133A5033323935 @default.
• W2961061133 hasAuthorship W2961061133A5062157046 @default.
• W2961061133 hasAuthorship W2961061133A5062357593 @default.
• W2961061133 hasAuthorship W2961061133A5079825950 @default.
• W2961061133 hasAuthorship W2961061133A5090265444 @default.
• W2961061133 hasBestOaLocation W29610611331 @default.
• W2961061133 hasConcept C124490489 @default.
• W2961061133 hasConcept C126189478 @default.
• W2961061133 hasConcept C126322002 @default.
• W2961061133 hasConcept C159641895 @default.
• W2961061133 hasConcept C16005928 @default.
• W2961061133 hasConcept C2776940978 @default.
• W2961061133 hasConcept C2778653478 @default.
• W2961061133 hasConcept C2779548794 @default.
• W2961061133 hasConcept C2779629538 @default.
• W2961061133 hasConcept C2779740938 @default.
• W2961061133 hasConcept C2780091579 @default.
• W2961061133 hasConcept C71924100 @default.
• W2961061133 hasConcept C90924648 @default.
• W2961061133 hasConcept C98274493 @default.
• W2961061133 hasConceptScore W2961061133C124490489 @default.
• W2961061133 hasConceptScore W2961061133C126189478 @default.
• W2961061133 hasConceptScore W2961061133C126322002 @default.
• W2961061133 hasConceptScore W2961061133C159641895 @default.
• W2961061133 hasConceptScore W2961061133C16005928 @default.
• W2961061133 hasConceptScore W2961061133C2776940978 @default.
• W2961061133 hasConceptScore W2961061133C2778653478 @default.
• W2961061133 hasConceptScore W2961061133C2779548794 @default.
• W2961061133 hasConceptScore W2961061133C2779629538 @default.
• W2961061133 hasConceptScore W2961061133C2779740938 @default.
• W2961061133 hasConceptScore W2961061133C2780091579 @default.
• W2961061133 hasConceptScore W2961061133C71924100 @default.
• W2961061133 hasConceptScore W2961061133C90924648 @default.
• W2961061133 hasConceptScore W2961061133C98274493 @default.
• W2961061133 hasFunder F4320320997 @default.
• W2961061133 hasIssue "7" @default.

• next