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- W2961210149 abstract "Cellular metabolic reprogramming is an important mechanism by which cells rewire their metabolism to promote proliferation and cell growth. This process has been mostly studied in the context of tumorigenesis and less is known about its relevance for non-pathological processes and how it affects whole animal physiology. Here, we show that Drosophila female germline cells reprogram their carbohydrate metabolism, upregulating the pentose phosphate pathway (PPP) to produce eggs. Strikingly, this cellular reprogramming strongly impacts nutrient preferences. PPP activity in the germline specifically increases the animal’s appetite for sugar, the key nutrient fueling this metabolic pathway. We furthermore provide functional evidence that the germline alters sugar appetite by regulating the expression of the fat body secreted satiety factor fit . The cellular metabolic program of a small set of cells is therefore able to increase the animal’s preference for specific nutrients through inter-organ communication to promote specific metabolic and cellular outcomes." @default.
- W2961210149 created "2019-07-23" @default.
- W2961210149 creator A5039924803 @default.
- W2961210149 creator A5051645783 @default.
- W2961210149 creator A5070746297 @default.
- W2961210149 creator A5079341470 @default.
- W2961210149 date "2019-07-16" @default.
- W2961210149 modified "2023-09-27" @default.
- W2961210149 title "Cellular metabolic reprogramming controls sugar appetite" @default.
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- W2961210149 doi "https://doi.org/10.1101/704783" @default.
- W2961210149 hasPublicationYear "2019" @default.
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