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• W2961341318 abstract "The dynamics of tumor progression is driven by multiple factors, which can be exogenous to the tumor (microenvironment) or intrinsic (genetic, epigenetic or due to intercellular interactions). While tumor heterogeneity has been extensively studied on the level of cell genetic profiles or cellular composition, tumor morphological diversity has not been given as much attention. The limited analysis of tumor morphophenotypes may be attributed to the lack of accurate models, both experimental and computational, capable of capturing changes in tumor morphology with fine levels of spatial detail. Using a three-dimensional, agent-based, lattice-free computational model, we generated a library of multicellular tumor organoids, the experimental analogues of in vivo tumors. By varying three biologically relevant parameters-cell radius, cell division age and cell sensitivity to contact inhibition, we showed that tumor organoids with similar growth dynamics can express distinct morphologies and possess diverse cellular compositions. Taking advantage of the high-resolution of computational modeling, we applied the quantitative measures of compactness and accessible surface area, concepts that originated from the structural biology of proteins. Based on these analyses, we demonstrated that tumor organoids with similar sizes may differ in features associated with drug effectiveness, such as potential exposure to the drug or the extent of drug penetration. Both these characteristics might lead to major differences in tumor organoid's response to therapy. This indicates that therapeutic protocols should not be based solely on tumor size, but take into account additional tumor features, such as their morphology or cellular packing density." @default.
• W2961341318 created "2019-07-23" @default.
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• W2961341318 date "2019-07-16" @default.
• W2961341318 modified "2023-10-14" @default.
• W2961341318 title "Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential" @default.
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• W2961341318 doi "https://doi.org/10.1371/journal.pcbi.1007214" @default.
• W2961341318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6660094" @default.
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• W2961341318 hasPublicationYear "2019" @default.
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