Matches in SemOpenAlex for { <https://semopenalex.org/work/W2961449183> ?p ?o ?g. }
- W2961449183 abstract "Abstract The voltage-gated K + channel Kv2.1 serves a major structural role in the soma and proximal dendrites of brain neurons, tethering the plasma membrane (PM) to the endoplasmic reticulum (ER). Although Kv2.1 clustering at neuronal ER-PM junctions (EPJs) is tightly regulated and conserved across species, its function at these sites is unclear. By identifying and evaluating proteins in close spatial proximity to Kv2.1-containing EPJs, we discovered that a significant role of Kv2.1 at EPJs is to promote the clustering and functional coupling of PM L-type Ca 2+ channels (LTCCs) to ryanodine receptor (RyR) ER Ca 2+ release channels. Kv2.1 clustering also unexpectedly enhanced LTCC opening at polarized membrane potentials. This enabled Kv2.1-LTCC-RyR triads to generate localized Ca 2+ release events (i.e., Ca 2+ sparks) independently of action potentials. Together, these findings uncover a novel mode of LTCC regulation and establish a unique mechanism whereby Kv2.1-associated EPJs provide a molecular platform for localized somatodendritic Ca 2+ signals." @default.
- W2961449183 created "2019-07-23" @default.
- W2961449183 creator A5009453131 @default.
- W2961449183 creator A5041702675 @default.
- W2961449183 creator A5047555131 @default.
- W2961449183 creator A5056884743 @default.
- W2961449183 creator A5083775247 @default.
- W2961449183 date "2019-07-13" @default.
- W2961449183 modified "2023-10-17" @default.
- W2961449183 title "Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in neurons" @default.
- W2961449183 cites W1497761455 @default.
- W2961449183 cites W1582868277 @default.
- W2961449183 cites W1600171386 @default.
- W2961449183 cites W1646051950 @default.
- W2961449183 cites W1823064334 @default.
- W2961449183 cites W1900500057 @default.
- W2961449183 cites W1921440755 @default.
- W2961449183 cites W1973401628 @default.
- W2961449183 cites W1974360309 @default.
- W2961449183 cites W1977584840 @default.
- W2961449183 cites W1978193582 @default.
- W2961449183 cites W1979106875 @default.
- W2961449183 cites W1980385275 @default.
- W2961449183 cites W1981960751 @default.
- W2961449183 cites W1983231052 @default.
- W2961449183 cites W1983772092 @default.
- W2961449183 cites W1984574127 @default.
- W2961449183 cites W1984900040 @default.
- W2961449183 cites W1987229328 @default.
- W2961449183 cites W1988886754 @default.
- W2961449183 cites W1996227667 @default.
- W2961449183 cites W1996589818 @default.
- W2961449183 cites W2000072607 @default.
- W2961449183 cites W2001751033 @default.
- W2961449183 cites W2002864116 @default.
- W2961449183 cites W2003179114 @default.
- W2961449183 cites W2004583716 @default.
- W2961449183 cites W2008392372 @default.
- W2961449183 cites W2009292667 @default.
- W2961449183 cites W2009697737 @default.
- W2961449183 cites W2010170987 @default.
- W2961449183 cites W2011028126 @default.
- W2961449183 cites W2016489131 @default.
- W2961449183 cites W2023959801 @default.
- W2961449183 cites W2027803492 @default.
- W2961449183 cites W2031426087 @default.
- W2961449183 cites W2032362466 @default.
- W2961449183 cites W2032455525 @default.
- W2961449183 cites W2035460326 @default.
- W2961449183 cites W2039319290 @default.
- W2961449183 cites W2041119907 @default.
- W2961449183 cites W2042071353 @default.
- W2961449183 cites W2042210724 @default.
- W2961449183 cites W2043225986 @default.
- W2961449183 cites W2044049987 @default.
- W2961449183 cites W2054146070 @default.
- W2961449183 cites W2054225000 @default.
- W2961449183 cites W2054804998 @default.
- W2961449183 cites W2061046931 @default.
- W2961449183 cites W2061220110 @default.
- W2961449183 cites W2063972551 @default.
- W2961449183 cites W2068514166 @default.
- W2961449183 cites W2070664866 @default.
- W2961449183 cites W2073674965 @default.
- W2961449183 cites W2075636379 @default.
- W2961449183 cites W2078836693 @default.
- W2961449183 cites W2079762354 @default.
- W2961449183 cites W2080633827 @default.
- W2961449183 cites W2081110326 @default.
- W2961449183 cites W2082338288 @default.
- W2961449183 cites W2085856731 @default.
- W2961449183 cites W2086684841 @default.
- W2961449183 cites W2086998659 @default.
- W2961449183 cites W2087188546 @default.
- W2961449183 cites W2087981036 @default.
- W2961449183 cites W2088019372 @default.
- W2961449183 cites W2096701787 @default.
- W2961449183 cites W2099949778 @default.
- W2961449183 cites W2108154704 @default.
- W2961449183 cites W2109234881 @default.
- W2961449183 cites W2111009586 @default.
- W2961449183 cites W2112163644 @default.
- W2961449183 cites W2122916910 @default.
- W2961449183 cites W2126176864 @default.
- W2961449183 cites W2126308098 @default.
- W2961449183 cites W2127442418 @default.
- W2961449183 cites W2128103118 @default.
- W2961449183 cites W2129351481 @default.
- W2961449183 cites W2132703716 @default.
- W2961449183 cites W2138773108 @default.
- W2961449183 cites W2139909390 @default.
- W2961449183 cites W2148129999 @default.
- W2961449183 cites W2151619201 @default.
- W2961449183 cites W2151942667 @default.
- W2961449183 cites W2159048245 @default.
- W2961449183 cites W2163781490 @default.
- W2961449183 cites W2165126772 @default.
- W2961449183 cites W2167657931 @default.
- W2961449183 cites W2168897337 @default.
- W2961449183 cites W2169079203 @default.