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- W2961969275 endingPage "4029" @default.
- W2961969275 startingPage "4007" @default.
- W2961969275 abstract "Pausing by RNA polymerase (RNAP) during transcription regulates gene expression in all domains of life. In this review, we recap the history of transcriptional pausing discovery, summarize advances in our understanding of the underlying causes of pausing since then, and describe new insights into the pausing mechanisms and pause modulation by transcription factors gained from structural and biochemical experiments. The accumulated evidence to date suggests that upon encountering a pause signal in the nucleic-acid sequence being transcribed, RNAP rearranges into an elemental, catalytically inactive conformer unable to load NTP substrate. The conformation, and as a consequence lifetime, of an elemental paused RNAP is modulated by backtracking, nascent RNA structure, binding of transcription regulators, or a combination of these mechanisms. We conclude the review by outlining open questions and directions for future research in the field of transcriptional pausing." @default.
- W2961969275 created "2019-07-23" @default.
- W2961969275 creator A5000754139 @default.
- W2961969275 creator A5010325555 @default.
- W2961969275 creator A5033443967 @default.
- W2961969275 creator A5069772661 @default.
- W2961969275 date "2019-09-01" @default.
- W2961969275 modified "2023-10-12" @default.
- W2961969275 title "Mechanisms of Transcriptional Pausing in Bacteria" @default.
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