FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2961973247> ?p ?o ?g. }

• W2961973247 abstract "Wntless (Wls) is a protein that regulates secretion of Wnt signaling molecules from Wnt-producing cells. Wnt signaling is known to be critical for several developmental and homeostatic processes. However, Wnt-independent functions of Wls are now being elucidated. Primates express an alternative splice variant of Wls (here termed WlsX). WlsX contains an alternatively spliced COOH-terminus, and does not appear to be able to sustain significant levels of WNT secretion because of its inability to undergo retrograde trafficking to the endoplasmic reticulum. The functional significance for this alternatively spliced form of Wls has not yet been elucidated. We previously identified a cohort of Wls interacting proteins using a combination of yeast 2-hybrid and candidate gene approaches. In the present study, we analyzed the interaction of WlsX with previously identified Wls interactors, and additionally screened for novel protein interactors of WlsX utilizing a membrane yeast two hybrid screen. Three novel Wls interactors, Glycoprotein M6A (GPM6A), Alkylglycerol Monooxygenase (AGMO), and ORAI1 were identified. Each of these novel WlsX interactors, as well as all other Wls interacting proteins identified previously, with the exception of the mu-opioid receptor, were found to interact with both Wls and WlsX splice forms. We show that WlsX can form homodimers, but that WlsX may not interact with Wls. WlsX has the ability to form homodimers and to interact with most known Wls interacting proteins. Taken together, our results suggest that Wls and WlsX may have overlapping, but distinct functions, including sensitivity to opioid drugs. While studies have focused on the ability of Wls interacting proteins to affect Wnt secretion, future efforts will explore the reciprocal regulation of these proteins by Wls, possibly via Wnt-independent mechanisms." @default.
• W2961973247 created "2019-07-23" @default.
• W2961973247 creator A5001315042 @default.
• W2961973247 creator A5003595741 @default.
• W2961973247 creator A5012313326 @default.
• W2961973247 creator A5017384025 @default.
• W2961973247 creator A5032342197 @default.
• W2961973247 date "2019-07-08" @default.
• W2961973247 modified "2023-10-16" @default.
• W2961973247 title "Alternative splicing of the Wnt trafficking protein, Wntless and its effects on protein-protein interactions" @default.
• W2961973247 cites W1552956347 @default.
• W2961973247 cites W156513061 @default.
• W2961973247 cites W1925877006 @default.
• W2961973247 cites W1963879728 @default.
• W2961973247 cites W1969559038 @default.
• W2961973247 cites W1977462853 @default.
• W2961973247 cites W1983796869 @default.
• W2961973247 cites W1985875533 @default.
• W2961973247 cites W1985945295 @default.
• W2961973247 cites W1999408122 @default.
• W2961973247 cites W2003362984 @default.
• W2961973247 cites W2003731107 @default.
• W2961973247 cites W2011287700 @default.
• W2961973247 cites W2025453970 @default.
• W2961973247 cites W2029311374 @default.
• W2961973247 cites W2035343156 @default.
• W2961973247 cites W2036012822 @default.
• W2961973247 cites W2039313867 @default.
• W2961973247 cites W2047602427 @default.
• W2961973247 cites W2049389808 @default.
• W2961973247 cites W2058750858 @default.
• W2961973247 cites W2067937471 @default.
• W2961973247 cites W2068697596 @default.
• W2961973247 cites W2073365737 @default.
• W2961973247 cites W2073914665 @default.
• W2961973247 cites W2077776663 @default.
• W2961973247 cites W2078366752 @default.
• W2961973247 cites W2085793379 @default.
• W2961973247 cites W2090272171 @default.
• W2961973247 cites W2094001857 @default.
• W2961973247 cites W2106246537 @default.
• W2961973247 cites W2120419344 @default.
• W2961973247 cites W2147167742 @default.
• W2961973247 cites W2147864074 @default.
• W2961973247 cites W2161428975 @default.
• W2961973247 cites W2165924903 @default.
• W2961973247 cites W2167896883 @default.
• W2961973247 cites W2170748523 @default.
• W2961973247 cites W2171779714 @default.
• W2961973247 cites W2241789450 @default.
• W2961973247 cites W2326956930 @default.
• W2961973247 cites W2430421449 @default.
• W2961973247 cites W2533724268 @default.
• W2961973247 cites W2538590497 @default.
• W2961973247 cites W2540051414 @default.
• W2961973247 cites W2571142042 @default.
• W2961973247 cites W2576097024 @default.
• W2961973247 cites W2593429864 @default.
• W2961973247 cites W2733060293 @default.
• W2961973247 cites W2736337406 @default.
• W2961973247 cites W2745476773 @default.
• W2961973247 cites W2754331242 @default.
• W2961973247 cites W2770941605 @default.
• W2961973247 cites W2802837568 @default.
• W2961973247 cites W2805309434 @default.
• W2961973247 doi "https://doi.org/10.1186/s12860-019-0208-1" @default.
• W2961973247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6615345" @default.
• W2961973247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31286866" @default.
• W2961973247 hasPublicationYear "2019" @default.
• W2961973247 type Work @default.
• W2961973247 sameAs 2961973247 @default.
• W2961973247 citedByCount "4" @default.
• W2961973247 countsByYear W29619732472020 @default.
• W2961973247 countsByYear W29619732472021 @default.
• W2961973247 countsByYear W29619732472023 @default.
• W2961973247 crossrefType "journal-article" @default.
• W2961973247 hasAuthorship W2961973247A5001315042 @default.
• W2961973247 hasAuthorship W2961973247A5003595741 @default.
• W2961973247 hasAuthorship W2961973247A5012313326 @default.
• W2961973247 hasAuthorship W2961973247A5017384025 @default.
• W2961973247 hasAuthorship W2961973247A5032342197 @default.
• W2961973247 hasBestOaLocation W29619732471 @default.
• W2961973247 hasConcept C104317684 @default.
• W2961973247 hasConcept C105580179 @default.
• W2961973247 hasConcept C137620995 @default.
• W2961973247 hasConcept C158617107 @default.
• W2961973247 hasConcept C170493617 @default.
• W2961973247 hasConcept C194583182 @default.
• W2961973247 hasConcept C24530287 @default.
• W2961973247 hasConcept C54355233 @default.
• W2961973247 hasConcept C62478195 @default.
• W2961973247 hasConcept C70721500 @default.
• W2961973247 hasConcept C86803240 @default.
• W2961973247 hasConcept C95444343 @default.
• W2961973247 hasConceptScore W2961973247C104317684 @default.
• W2961973247 hasConceptScore W2961973247C105580179 @default.
• W2961973247 hasConceptScore W2961973247C137620995 @default.
• W2961973247 hasConceptScore W2961973247C158617107 @default.
• W2961973247 hasConceptScore W2961973247C170493617 @default.
• W2961973247 hasConceptScore W2961973247C194583182 @default.

• next