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• W2962023691 abstract "Premature adrenarche (PA) is associated with childhood overweight and hyperinsulinemia; the long-term cardiometabolic outcome is unknown.To study cardiometabolic profile in adult women with previous PA.Thirty women with PA and 41 control subjects were followed from prepuberty to young adulthood.Prevalence of the metabolic syndrome (MetS) and clinical and biochemical cardiovascular risk factors.There were no differences in the prevalence of MetS or in any parameters indicating dyslipidemia, hypertension, hepatosteatosis, atherosclerosis, or low-grade inflammation between the study groups. However, prevalence of insulin resistance (IR; P = 0.014) and acanthosis nigricans (P = 0.010) was higher in the PA group. Neither fasting glucose nor insulin concentrations differed between the study groups, but HbA1c [adjusted for body mass index (BMI) P = 0.011] and Homeostatic Model Assessment of Insulin Resistance (P = 0.044; BMI-adjusted P = nonsignificant) were higher in the PA group. Although BMI and fat percentage were comparable between the study groups, the PA group had higher central fat mass than the control group. In the whole study population, MetS and IR were associated with greater adult fat mass, but no prepubertal factors predicting later IR were found.PA does not seem to be associated with MetS, dyslipidemia, hypertension, atherosclerosis, or low-grade inflammation in young adult women. However, some women with PA may be at an increased risk of unfavorable glucose metabolism, which is associated with increased central adiposity at adult age rather than determined by prepubertal factors." @default.
• W2962023691 created "2019-07-23" @default.
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• W2962023691 date "2019-07-15" @default.
• W2962023691 modified "2023-10-14" @default.
• W2962023691 title "Cardiometabolic Risk Profile Among Young Adult Females With a History of Premature Adrenarche" @default.
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• W2962023691 doi "https://doi.org/10.1210/js.2019-00193" @default.
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