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- W2962074785 endingPage "239" @default.
- W2962074785 startingPage "215" @default.
- W2962074785 abstract "Abstract While reports praised the significant improvement in clinical lab analyses due to automation and implementation of internal and external quality tools, lack of traceability and the concept of gold standard is making clinical lab quality as a moving object with no hope to get better but, instead, worsen by time. Revealing real-life data, this chapter shows unbelievable discrepancies in biomarker results with its imminent disastrous impact on patients and drug discovery. Results from a single sample can be different by as much as more than 100-fold if analyzed by different labs or even by a single lab using different instruments. Just changing a lot of reagents can cause difference in results from a single sample that conceals a medical decision cutoff. These issues are not just in novel high complex molecular diagnostics but in grandfather, believed standardized, short list of assays such as lactate dehydrogenase, low-density lipoprotein cholesterol, and international normalized ratio." @default.
- W2962074785 created "2019-07-23" @default.
- W2962074785 creator A5037455342 @default.
- W2962074785 date "2019-01-01" @default.
- W2962074785 modified "2023-10-18" @default.
- W2962074785 title "Analytical discrepancies and their potential impact on biomarkers and precision medicine initiative" @default.
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- W2962074785 doi "https://doi.org/10.1016/b978-0-12-816121-0.00010-6" @default.
- W2962074785 hasPublicationYear "2019" @default.
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