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- W2962187296 abstract "Livistona chinensis fruit is a traditional Chinese medicine widely used for treating hepatitis, but its protective effect against hepatitis remains unknown. This study investigated the hepatoprotective effect and mechanism of flavonoids from Livistona chinensis fruit (FLCF). Mice received FLCF pre-treatment for 7 days and induced liver injury with LPS+D-GalN. RAW264.7 cells were triggered inflammation by LPS and received FLCF for 24 h. The result showed that FLCF ameliorated the liver pathology in mice, decreased the levels of AST, ALT, MDA, but increased SOD and GSH. Moreover, FLCF inhibited TLR4/NF-κB signaling, while activated Nrf2/HO-1 signaling in LPS+D-GalN mice. These effects were consistent with the in vitro data revealing that FLCF suppressed TLR4/NF-κB signaling, while promoting Nrf2/HO-1 signaling in RAW264.7 cell. The effects of FLCF were neutralized by Nrf2 siRNA. Taken together, these results demonstrated that FLCF has a protective role against acute liver injury and supports its use as a dietotherapy." @default.
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- W2962187296 date "2019-10-01" @default.
- W2962187296 modified "2023-10-16" @default.
- W2962187296 title "Flavonoids from Livistona chinensis fruit ameliorates LPS/D-GalN-induced acute liver injury by inhibiting oxidative stress and inflammation" @default.
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- W2962187296 doi "https://doi.org/10.1016/j.jff.2019.103460" @default.
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