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• W2962220663 endingPage "59" @default.
• W2962220663 startingPage "47" @default.
• W2962220663 abstract "During probing and blood feeding, haematophagous mosquitoes inoculate a mixture of salivary molecules into their vertebrate hosts' skin. In addition to the anti-haemostatic and immunomodulatory activities, mosquito saliva also triggers acute inflammatory reactions, especially in sensitized hosts. Here, we characterize the oedema and the cellular infiltrate following Aedes aegypti mosquito bites in the skin of sensitized and non-sensitized BALB/c mice by flow cytometry. Ae. aegypti bites induced an increased oedema in the ears of both non-sensitized and salivary gland extract- (SGE-)sensitized mice, peaking at 6 hr and 24 hr after exposure, respectively. The quantification of the total cell number in the ears revealed that the cellular recruitment was more robust in SGE-sensitized mice than in non-sensitized mice, and the histological evaluation confirmed these findings. The immunophenotyping performed by flow cytometry revealed that mosquito bites were able to produce complex changes in cell populations present in the ears of non-sensitized and SGE-sensitized mice. When compared with steady-state ears, the leucocyte populations significantly recruited to the skin after mosquito bites in non-sensitized and sensitized mice were eosinophils, neutrophils, monocytes, inflammatory monocytes, mast cells, B-cells and CD4+ T-cells, each one with its specific kinetics. The changes in the absolute number of cells suggested two cell recruitment profiles: (i) a saliva-dependent migration; and (ii) a migration dependent on the immune status of the host. These findings suggest that mosquito bites influence the skin microenvironment by inducing differential cell migration, which is dependent on the degree of host sensitization to salivary molecules." @default.
• W2962220663 created "2019-07-23" @default.
• W2962220663 creator A5023204981 @default.
• W2962220663 creator A5034145088 @default.
• W2962220663 creator A5037024228 @default.
• W2962220663 creator A5044791054 @default.
• W2962220663 creator A5075990647 @default.
• W2962220663 creator A5079162334 @default.
• W2962220663 creator A5086292185 @default.
• W2962220663 creator A5087224849 @default.
• W2962220663 date "2019-08-19" @default.
• W2962220663 modified "2023-10-10" @default.
• W2962220663 title "Evaluation of inflammatory skin infiltrate following<i>Aedes aegypti</i>bites in sensitized and non‐sensitized mice reveals saliva‐dependent and immune‐dependent phenotypes" @default.
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