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• W2962261208 abstract "Due to the sustained prevalence of HIV-1 associated neurocognitive disorders (HAND) in the post-cART era, as well as the increased prevalence of older HIV-1 seropositive individuals, there is a critical need to develop adjunctive therapeutics targeted at preserving and/or restoring neurocognitive function. To address this knowledge gap, the present study examined the utility of S-Equol (SE), a phytoestrogen produced by gut microbiota, as an innovative therapeutic strategy. A signal detection operant task with varying signal durations (1000, 500, 100 msec) was utilized to assess sustained attention in HIV-1 transgenic (Tg) and control animals. During the signal detection pretest assessment, HIV-1 Tg animals displayed profound deficits in stimulus-response learning and sustained attention relative to control animals. Subsequently, between 6 and 8 months of age, HIV-1 Tg and control animals were treated with a daily oral dose of either placebo or SE (0.05, 0.1, 0.2 mg) and a posttest assessment was conducted in the signal detection operant task with varying signal durations. In HIV-1 Tg animals, a linear decrease in the number of misses at 100 msec was observed as SE dose increased, suggesting a dose response with the most effective dose at 0.2 mg SE, approximating controls. Comparison of the number of misses across signal durations at the pretest and posttest revealed a preservation of neurocognitive function in HIV-1 Tg animals treated with 0.2 mg SE; an effect that was in sharp contrast to the neurocognitive decline observed in HIV-1 Tg animals treated with placebo. Results support the utility of 0.2 mg SE as a potential efficacious neuroprotective and/or neurorestorative therapeutic for sustained attention, in the absence of any adverse peripheral effects, in the HIV-1 Tg rat. Thus, the present study highlights the critical need for further in vivo studies to elucidate the full potential and generalizability of phytoestrogen treatment for HAND." @default.
• W2962261208 created "2019-07-23" @default.
• W2962261208 creator A5026901655 @default.
• W2962261208 creator A5029143320 @default.
• W2962261208 creator A5047436104 @default.
• W2962261208 creator A5072328863 @default.
• W2962261208 date "2019-08-06" @default.
• W2962261208 modified "2023-10-11" @default.
• W2962261208 title "Neurorestoration of Sustained Attention in a Model of HIV-1 Associated Neurocognitive Disorders" @default.
• W2962261208 cites W1496341906 @default.
• W2962261208 cites W1547213639 @default.
• W2962261208 cites W1623065404 @default.
• W2962261208 cites W1836695475 @default.
• W2962261208 cites W1903888485 @default.
• W2962261208 cites W1913367972 @default.
• W2962261208 cites W1920510593 @default.
• W2962261208 cites W1967324141 @default.
• W2962261208 cites W1968221083 @default.
• W2962261208 cites W1973793211 @default.
• W2962261208 cites W1973929699 @default.
• W2962261208 cites W1975622423 @default.
• W2962261208 cites W1977020129 @default.
• W2962261208 cites W1977104590 @default.
• W2962261208 cites W1979334603 @default.
• W2962261208 cites W1980274902 @default.
• W2962261208 cites W1994827009 @default.
• W2962261208 cites W1998431562 @default.
• W2962261208 cites W2001005763 @default.
• W2962261208 cites W2001339909 @default.
• W2962261208 cites W2002890468 @default.
• W2962261208 cites W2003852109 @default.
• W2962261208 cites W2005475021 @default.
• W2962261208 cites W2015316640 @default.
• W2962261208 cites W2017243530 @default.
• W2962261208 cites W2027798298 @default.
• W2962261208 cites W2030500910 @default.
• W2962261208 cites W2033327108 @default.
• W2962261208 cites W2036619379 @default.
• W2962261208 cites W2039441471 @default.
• W2962261208 cites W2040933166 @default.
• W2962261208 cites W2045304025 @default.
• W2962261208 cites W2055558890 @default.
• W2962261208 cites W2058218622 @default.
• W2962261208 cites W2060115605 @default.
• W2962261208 cites W2061845693 @default.
• W2962261208 cites W2062526841 @default.
• W2962261208 cites W2065104437 @default.
• W2962261208 cites W2068084209 @default.
• W2962261208 cites W2069567007 @default.
• W2962261208 cites W2073384621 @default.
• W2962261208 cites W2076188595 @default.
• W2962261208 cites W2089059898 @default.
• W2962261208 cites W2093705952 @default.
• W2962261208 cites W2094205706 @default.
• W2962261208 cites W2097515723 @default.
• W2962261208 cites W2102182468 @default.
• W2962261208 cites W2104260362 @default.
• W2962261208 cites W2114379216 @default.
• W2962261208 cites W2116841805 @default.
• W2962261208 cites W2118089000 @default.
• W2962261208 cites W2123874519 @default.
• W2962261208 cites W2130599091 @default.
• W2962261208 cites W2133169879 @default.
• W2962261208 cites W2138294676 @default.
• W2962261208 cites W2140590679 @default.
• W2962261208 cites W2144046237 @default.
• W2962261208 cites W2147626688 @default.
• W2962261208 cites W2158666805 @default.
• W2962261208 cites W2158703764 @default.
• W2962261208 cites W2162723667 @default.
• W2962261208 cites W2163840069 @default.
• W2962261208 cites W2170850530 @default.
• W2962261208 cites W2239411622 @default.
• W2962261208 cites W2255595836 @default.
• W2962261208 cites W2257701683 @default.
• W2962261208 cites W2292048640 @default.
• W2962261208 cites W2295774726 @default.
• W2962261208 cites W2296527675 @default.
• W2962261208 cites W2333763415 @default.
• W2962261208 cites W2337536067 @default.
• W2962261208 cites W2468491886 @default.
• W2962261208 cites W2514207301 @default.
• W2962261208 cites W2514371044 @default.
• W2962261208 cites W2527760515 @default.
• W2962261208 cites W2561086971 @default.
• W2962261208 cites W2567432104 @default.
• W2962261208 cites W2587539025 @default.
• W2962261208 cites W2598934409 @default.
• W2962261208 cites W2601297103 @default.
• W2962261208 cites W2635986780 @default.
• W2962261208 cites W2735033316 @default.
• W2962261208 cites W2738123242 @default.
• W2962261208 cites W2751953804 @default.
• W2962261208 cites W2767658959 @default.
• W2962261208 cites W2769479254 @default.
• W2962261208 cites W2779074592 @default.
• W2962261208 cites W2793674588 @default.
• W2962261208 cites W2805985949 @default.
• W2962261208 cites W2885227302 @default.
• W2962261208 cites W2900861046 @default.

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