Matches in SemOpenAlex for { <https://semopenalex.org/work/W2962392431> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2962392431 abstract "ABSTRACT Upon replication in mucosal epithelia and transmission to nerve endings, capsids of herpes simplex virus type I (HSV-1) travel retrograde within axons to peripheral ganglia where life-long latent infections are established. A capsid-bound tegument protein, pUL37, is an essential effector of retrograde axonal transport and also houses a deamidase activity that antagonizes innate immune signaling. In this report, we examined whether the deamidase of HSV-1 pUL37 contributes to the neuroinvasive retrograde axonal transport mechanism. We conclude that neuroinvasion is enhanced by the deamidase, but the critical contribution of pUL37 to retrograde axonal transport functions independently of this activity. IMPORTANCE Herpes simplex virus type 1 invades the nervous system by entering nerve endings and sustaining long-distance retrograde axonal transport to reach neuronal nuclei in ganglia of the peripheral nervous system. The incoming viral particle carries a deamidase activity on its surface that antagonizes antiviral responses. We examined the contribution of the deamidase to the hallmark neuroinvasive property of this virus." @default.
- W2962392431 created "2019-07-23" @default.
- W2962392431 creator A5017371611 @default.
- W2962392431 creator A5041566886 @default.
- W2962392431 date "2019-07-16" @default.
- W2962392431 modified "2023-09-26" @default.
- W2962392431 title "The herpes simplex virus type I deamidase enhances propagation but is dispensable for retrograde axonal transport into the nervous system" @default.
- W2962392431 cites W1851333263 @default.
- W2962392431 cites W1975285829 @default.
- W2962392431 cites W1981421036 @default.
- W2962392431 cites W1988288150 @default.
- W2962392431 cites W1988736583 @default.
- W2962392431 cites W1996645439 @default.
- W2962392431 cites W2004533639 @default.
- W2962392431 cites W2005210883 @default.
- W2962392431 cites W2006226787 @default.
- W2962392431 cites W2007468876 @default.
- W2962392431 cites W2009043962 @default.
- W2962392431 cites W2027929104 @default.
- W2962392431 cites W2036839993 @default.
- W2962392431 cites W2044774188 @default.
- W2962392431 cites W2056896021 @default.
- W2962392431 cites W2071467437 @default.
- W2962392431 cites W2088835721 @default.
- W2962392431 cites W2093697057 @default.
- W2962392431 cites W2101998831 @default.
- W2962392431 cites W2102473073 @default.
- W2962392431 cites W2108518323 @default.
- W2962392431 cites W2108859569 @default.
- W2962392431 cites W2139707370 @default.
- W2962392431 cites W2141424564 @default.
- W2962392431 cites W2147469769 @default.
- W2962392431 cites W2150052212 @default.
- W2962392431 cites W2150346334 @default.
- W2962392431 cites W2150409982 @default.
- W2962392431 cites W2178984934 @default.
- W2962392431 cites W2549958644 @default.
- W2962392431 cites W2765196763 @default.
- W2962392431 cites W2773605327 @default.
- W2962392431 cites W2796156307 @default.
- W2962392431 cites W2885484032 @default.
- W2962392431 cites W4229638451 @default.
- W2962392431 doi "https://doi.org/10.1101/704338" @default.
- W2962392431 hasPublicationYear "2019" @default.
- W2962392431 type Work @default.
- W2962392431 sameAs 2962392431 @default.
- W2962392431 citedByCount "1" @default.
- W2962392431 countsByYear W29623924312019 @default.
- W2962392431 crossrefType "posted-content" @default.
- W2962392431 hasAuthorship W2962392431A5017371611 @default.
- W2962392431 hasAuthorship W2962392431A5041566886 @default.
- W2962392431 hasBestOaLocation W29623924311 @default.
- W2962392431 hasConcept C140704245 @default.
- W2962392431 hasConcept C159047783 @default.
- W2962392431 hasConcept C169760540 @default.
- W2962392431 hasConcept C202878990 @default.
- W2962392431 hasConcept C2522874641 @default.
- W2962392431 hasConcept C2781196997 @default.
- W2962392431 hasConcept C529278444 @default.
- W2962392431 hasConcept C545314008 @default.
- W2962392431 hasConcept C545706735 @default.
- W2962392431 hasConcept C70192387 @default.
- W2962392431 hasConcept C86803240 @default.
- W2962392431 hasConcept C95444343 @default.
- W2962392431 hasConceptScore W2962392431C140704245 @default.
- W2962392431 hasConceptScore W2962392431C159047783 @default.
- W2962392431 hasConceptScore W2962392431C169760540 @default.
- W2962392431 hasConceptScore W2962392431C202878990 @default.
- W2962392431 hasConceptScore W2962392431C2522874641 @default.
- W2962392431 hasConceptScore W2962392431C2781196997 @default.
- W2962392431 hasConceptScore W2962392431C529278444 @default.
- W2962392431 hasConceptScore W2962392431C545314008 @default.
- W2962392431 hasConceptScore W2962392431C545706735 @default.
- W2962392431 hasConceptScore W2962392431C70192387 @default.
- W2962392431 hasConceptScore W2962392431C86803240 @default.
- W2962392431 hasConceptScore W2962392431C95444343 @default.
- W2962392431 hasLocation W29623924311 @default.
- W2962392431 hasLocation W29623924312 @default.
- W2962392431 hasOpenAccess W2962392431 @default.
- W2962392431 hasPrimaryLocation W29623924311 @default.
- W2962392431 hasRelatedWork W1499615242 @default.
- W2962392431 hasRelatedWork W1993737194 @default.
- W2962392431 hasRelatedWork W2031467556 @default.
- W2962392431 hasRelatedWork W2106212487 @default.
- W2962392431 hasRelatedWork W2160058596 @default.
- W2962392431 hasRelatedWork W2163297119 @default.
- W2962392431 hasRelatedWork W2756633005 @default.
- W2962392431 hasRelatedWork W2971226067 @default.
- W2962392431 hasRelatedWork W3042925774 @default.
- W2962392431 hasRelatedWork W4220788934 @default.
- W2962392431 isParatext "false" @default.
- W2962392431 isRetracted "false" @default.
- W2962392431 magId "2962392431" @default.
- W2962392431 workType "article" @default.