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- W2962425302 abstract "The bicyclo[1.1.1]pentane (BCP) motif has been utilized as bioisosteres in drug candidates to replace phenyl, tert-butyl, and alkynyl fragments in order to improve physicochemical properties. However, bceause of the difficulty of synthesis, most BCP analogues prepared only bear 1,3-para-substituents. We report the first selective synthesis of 2,2-difluorobicyclo[1.1.1]pentanes via difluorocarbene insertion into bicyclo[1.1.0]butanes. Moreover, this methodology should inspire future studies on synthesis of other ortho/meta-substituted BCPs via similar mechanisms." @default.
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- W2962425302 date "2019-07-11" @default.
- W2962425302 modified "2023-10-18" @default.
- W2962425302 title "A Selective Synthesis of 2,2-Difluorobicyclo[1.1.1]pentane Analogues: “BCP-F<sub>2</sub>”" @default.
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- W2962425302 doi "https://doi.org/10.1021/acs.orglett.9b02026" @default.
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