FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2962447316> ?p ?o ?g. }

• W2962447316 abstract "Angiotensin-(1-7) is a beneficial hormone of the renin-angiotensin system known to play a positive role in regulation of blood pressure and glucose homeostasis. Previous studies have shown that in high-fat diet (HFD)-induced obese male mice, circulating angiotensin-(1-7) levels are reduced and chronic restoration of this hormone reverses diet-induced insulin resistance; however, this has yet to be examined in female mice. We hypothesized angiotensin-(1-7) would improve insulin sensitivity and glucose tolerance in obese female mice, to a similar extent as previously observed in male mice. Five-week-old male and female C57BL/6J mice (8–12/group) were placed on control diet or HFD (16% or 59% kcal from fat, respectively) for 11 weeks. After 8 weeks of diet, mice were implanted with an osmotic pump for 3-week subcutaneous delivery of angiotensin-(1-7) (400 ng/kg/min) or saline vehicle. During the last week of treatment, body mass and composition were measured and intraperitoneal insulin and glucose tolerance tests were performed to assess insulin sensitivity and glucose tolerance, respectively. Mice were euthanized at the end of the study for blood and tissue collection. HFD increased body mass and adiposity in both sexes. Chronic angiotensin-(1-7) infusion significantly decreased body mass and adiposity and increased lean mass in obese mice of both sexes. While both sexes tended to develop mild hyperglycemia in response to HFD, female mice developed less marked hyperinsulinemia. There was no effect of angiotensin-(1-7) on fasting glucose or insulin levels among diet and sex groups. Male and female mice similarly developed insulin resistance and glucose intolerance in response to HFD feeding. Angiotensin-(1-7) improved insulin sensitivity in both sexes but corrected glucose intolerance only in obese female mice. There were no effects of sex or angiotensin-(1-7) treatment on any of the study outcomes in control diet-fed mice. This study provides new evidence for sex differences in the impact of chronic angiotensin-(1-7) in obese mice, with females having greater changes in glucose tolerance with treatment. These findings improve understanding of sex differences in renin-angiotensin mechanisms in obesity and illustrate the potential for targeting angiotensin-(1-7) for treatment of this condition." @default.
• W2962447316 created "2019-07-23" @default.
• W2962447316 creator A5011163609 @default.
• W2962447316 creator A5020697647 @default.
• W2962447316 creator A5033432824 @default.
• W2962447316 creator A5039063713 @default.
• W2962447316 creator A5052662209 @default.
• W2962447316 creator A5071389166 @default.
• W2962447316 creator A5077929332 @default.
• W2962447316 creator A5089482599 @default.
• W2962447316 creator A5091103521 @default.
• W2962447316 date "2019-07-17" @default.
• W2962447316 modified "2023-10-17" @default.
• W2962447316 title "Sex differences in metabolic effects of angiotensin-(1-7) treatment in obese mice" @default.
• W2962447316 cites W11753821 @default.
• W2962447316 cites W1783727169 @default.
• W2962447316 cites W1963645020 @default.
• W2962447316 cites W1969932710 @default.
• W2962447316 cites W1971189207 @default.
• W2962447316 cites W1976599912 @default.
• W2962447316 cites W2002022639 @default.
• W2962447316 cites W2003389247 @default.
• W2962447316 cites W2016607503 @default.
• W2962447316 cites W2025387987 @default.
• W2962447316 cites W2025578932 @default.
• W2962447316 cites W2025802991 @default.
• W2962447316 cites W2027908588 @default.
• W2962447316 cites W2028521865 @default.
• W2962447316 cites W2035168927 @default.
• W2962447316 cites W2039635908 @default.
• W2962447316 cites W2051051050 @default.
• W2962447316 cites W2062854799 @default.
• W2962447316 cites W2076128586 @default.
• W2962447316 cites W2082844594 @default.
• W2962447316 cites W2092003450 @default.
• W2962447316 cites W2097852075 @default.
• W2962447316 cites W2101474131 @default.
• W2962447316 cites W2101576799 @default.
• W2962447316 cites W2117443901 @default.
• W2962447316 cites W2126676515 @default.
• W2962447316 cites W2137839491 @default.
• W2962447316 cites W2137919415 @default.
• W2962447316 cites W2138454032 @default.
• W2962447316 cites W2147194311 @default.
• W2962447316 cites W2157197482 @default.
• W2962447316 cites W2160217587 @default.
• W2962447316 cites W2166479242 @default.
• W2962447316 cites W2166530980 @default.
• W2962447316 cites W2258348456 @default.
• W2962447316 cites W2298963483 @default.
• W2962447316 cites W2414200861 @default.
• W2962447316 cites W2528371580 @default.
• W2962447316 cites W2565128245 @default.
• W2962447316 cites W2766597786 @default.
• W2962447316 cites W2774744396 @default.
• W2962447316 cites W2780715796 @default.
• W2962447316 cites W2902642167 @default.
• W2962447316 doi "https://doi.org/10.1186/s13293-019-0251-9" @default.
• W2962447316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6637512" @default.
• W2962447316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31315689" @default.
• W2962447316 hasPublicationYear "2019" @default.
• W2962447316 type Work @default.
• W2962447316 sameAs 2962447316 @default.
• W2962447316 citedByCount "13" @default.
• W2962447316 countsByYear W29624473162020 @default.
• W2962447316 countsByYear W29624473162021 @default.
• W2962447316 countsByYear W29624473162022 @default.
• W2962447316 countsByYear W29624473162023 @default.
• W2962447316 crossrefType "journal-article" @default.
• W2962447316 hasAuthorship W2962447316A5011163609 @default.
• W2962447316 hasAuthorship W2962447316A5020697647 @default.
• W2962447316 hasAuthorship W2962447316A5033432824 @default.
• W2962447316 hasAuthorship W2962447316A5039063713 @default.
• W2962447316 hasAuthorship W2962447316A5052662209 @default.
• W2962447316 hasAuthorship W2962447316A5071389166 @default.
• W2962447316 hasAuthorship W2962447316A5077929332 @default.
• W2962447316 hasAuthorship W2962447316A5089482599 @default.
• W2962447316 hasAuthorship W2962447316A5091103521 @default.
• W2962447316 hasBestOaLocation W29624473161 @default.
• W2962447316 hasConcept C126322002 @default.
• W2962447316 hasConcept C134018914 @default.
• W2962447316 hasConcept C198710026 @default.
• W2962447316 hasConcept C2777391703 @default.
• W2962447316 hasConcept C2779306644 @default.
• W2962447316 hasConcept C2780988686 @default.
• W2962447316 hasConcept C2908929049 @default.
• W2962447316 hasConcept C3018667095 @default.
• W2962447316 hasConcept C511355011 @default.
• W2962447316 hasConcept C63645605 @default.
• W2962447316 hasConcept C71315377 @default.
• W2962447316 hasConcept C71924100 @default.
• W2962447316 hasConcept C84393581 @default.
• W2962447316 hasConceptScore W2962447316C126322002 @default.
• W2962447316 hasConceptScore W2962447316C134018914 @default.
• W2962447316 hasConceptScore W2962447316C198710026 @default.
• W2962447316 hasConceptScore W2962447316C2777391703 @default.
• W2962447316 hasConceptScore W2962447316C2779306644 @default.
• W2962447316 hasConceptScore W2962447316C2780988686 @default.
• W2962447316 hasConceptScore W2962447316C2908929049 @default.
• W2962447316 hasConceptScore W2962447316C3018667095 @default.

• next