Matches in SemOpenAlex for { <https://semopenalex.org/work/W2962523013> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2962523013 endingPage "2637" @default.
- W2962523013 startingPage "2637" @default.
- W2962523013 abstract "Scaffolds are the adaptable tools for the treatment of diabetic wounds, In this study, Simvastatin was loaded in polycaprolactone-collagen scaffolds for the treatment of diabetic foot ulcer using the freeze-drying technique. Eventually scaffolds characterization were observed in terms of Scanning Electron Microscopy, Differential scanning calorimetry (DSC), Porosity, Water absorption test, Matrix degradation, In vitro drug release studies, cell proliferation assay, cytotoxicity assay. Scaffolds prepared with polycaprolactone and collagen-polymer showed the homogeneous distribution with high porosity, extended biodegradation rate, high water uptake. All the scaffold formulation showed the sustained drug release and then a plateau. The cross-Linked scaffold has significant slower release in comparison to non-crosslinked scaffold, this is because of cross-linking of the scaffolds where the chemical and mechanical bonding is high compared to non-crosslinked scaffold, Noncrosslinked, showed 85.34% of drug release by this it can be concluded that non cross-linked scaffolds showed the prolonged release, In the cell proliferation assay after 72 h, the cell growth was found to be greater when we compared with placebo and control due to the presence of drug, which explains that the cells are in logarithmic phase. Noncross linked scaffold has shown an increase in cell growth by 28% from its initial value. In Differential Scanning Calorimetry (DSC) shows that there is no change in the peaks by that we can confirm that all the excipients are compatible to each other The obtained results imply that the investigated scaffold is a potential candidate for skin regeneration application because the present study states that simvastatin is having all the properties to treat the Diabetic Foot Ulcer(DFU) without producing the resistance." @default.
- W2962523013 created "2019-07-23" @default.
- W2962523013 creator A5006456528 @default.
- W2962523013 creator A5019016711 @default.
- W2962523013 creator A5072515512 @default.
- W2962523013 creator A5075936988 @default.
- W2962523013 date "2019-01-01" @default.
- W2962523013 modified "2023-09-25" @default.
- W2962523013 title "Simvastatin Loaded Polycaprolactone-collagen Scaffolds for the treatment of Diabetic Foot Ulcer" @default.
- W2962523013 doi "https://doi.org/10.5958/0974-360x.2019.00441.4" @default.
- W2962523013 hasPublicationYear "2019" @default.
- W2962523013 type Work @default.
- W2962523013 sameAs 2962523013 @default.
- W2962523013 citedByCount "4" @default.
- W2962523013 countsByYear W29625230132022 @default.
- W2962523013 countsByYear W29625230132023 @default.
- W2962523013 crossrefType "journal-article" @default.
- W2962523013 hasAuthorship W2962523013A5006456528 @default.
- W2962523013 hasAuthorship W2962523013A5019016711 @default.
- W2962523013 hasAuthorship W2962523013A5072515512 @default.
- W2962523013 hasAuthorship W2962523013A5075936988 @default.
- W2962523013 hasConcept C126322002 @default.
- W2962523013 hasConcept C134018914 @default.
- W2962523013 hasConcept C136229726 @default.
- W2962523013 hasConcept C159985019 @default.
- W2962523013 hasConcept C192562407 @default.
- W2962523013 hasConcept C2776329913 @default.
- W2962523013 hasConcept C2777858829 @default.
- W2962523013 hasConcept C2778144972 @default.
- W2962523013 hasConcept C2779868350 @default.
- W2962523013 hasConcept C2910357528 @default.
- W2962523013 hasConcept C521977710 @default.
- W2962523013 hasConcept C555293320 @default.
- W2962523013 hasConcept C71924100 @default.
- W2962523013 hasConceptScore W2962523013C126322002 @default.
- W2962523013 hasConceptScore W2962523013C134018914 @default.
- W2962523013 hasConceptScore W2962523013C136229726 @default.
- W2962523013 hasConceptScore W2962523013C159985019 @default.
- W2962523013 hasConceptScore W2962523013C192562407 @default.
- W2962523013 hasConceptScore W2962523013C2776329913 @default.
- W2962523013 hasConceptScore W2962523013C2777858829 @default.
- W2962523013 hasConceptScore W2962523013C2778144972 @default.
- W2962523013 hasConceptScore W2962523013C2779868350 @default.
- W2962523013 hasConceptScore W2962523013C2910357528 @default.
- W2962523013 hasConceptScore W2962523013C521977710 @default.
- W2962523013 hasConceptScore W2962523013C555293320 @default.
- W2962523013 hasConceptScore W2962523013C71924100 @default.
- W2962523013 hasIssue "6" @default.
- W2962523013 hasLocation W29625230131 @default.
- W2962523013 hasOpenAccess W2962523013 @default.
- W2962523013 hasPrimaryLocation W29625230131 @default.
- W2962523013 hasRelatedWork W2077321957 @default.
- W2962523013 hasRelatedWork W2124957132 @default.
- W2962523013 hasRelatedWork W2366305344 @default.
- W2962523013 hasRelatedWork W2389992670 @default.
- W2962523013 hasRelatedWork W2530350521 @default.
- W2962523013 hasRelatedWork W2604922190 @default.
- W2962523013 hasRelatedWork W2763046336 @default.
- W2962523013 hasRelatedWork W2981847501 @default.
- W2962523013 hasRelatedWork W4318213440 @default.
- W2962523013 hasRelatedWork W3144878865 @default.
- W2962523013 hasVolume "12" @default.
- W2962523013 isParatext "false" @default.
- W2962523013 isRetracted "false" @default.
- W2962523013 magId "2962523013" @default.
- W2962523013 workType "article" @default.