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- W2962605392 abstract "Purpose of the ReviewThe success of Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans as fungal pathogens depends on their rapid adaptation to host microenvironments, through metabolic remodeling, stress resistance, and expression of virulence determinants. Amino acids represent an abundant nitrogen and carbon source within the host; however, their acquisition by fungi is a very complex process that interconnects several sensory and uptake systems and downstream pathways. In this review, we will summarize the current knowledge concerning this topic, identify gaps or discrepancies, and discuss future research directions.Recent FindingsAside from supporting basic cellular functions, the utilization of many amino acids has a direct effect on fungal pathogenicity by triggering key virulence traits, including hyphal morphogenesis and biofilm growth in C. albicans, capsule formation in C. neoformans, and melanization in A. fumigatus.SummaryAlthough many components of amino acid sensing and metabolism are fungal specific, their importance in infection and potential as candidates for antifungal drug development require further investigation." @default.
- W2962605392 created "2019-07-23" @default.
- W2962605392 creator A5023809168 @default.
- W2962605392 creator A5087132680 @default.
- W2962605392 date "2019-07-17" @default.
- W2962605392 modified "2023-10-14" @default.
- W2962605392 title "Role of Amino Acid Metabolism in the Virulence of Human Pathogenic Fungi" @default.
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