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- W2962676493 abstract "Pituitary Tumor Transforming Gene (PTTG) of human is known as a checkpoint gene in the middle and late stages of mitosis, and is also a proto-oncogene that promotes cell cycle progression. In the nucleus, PTTG works as securin in controlling the mid-term segregation of sister chromatids. Overexpression of PTTG, entering the nucleus with the help of PBF in pituitary adenomas, participates in the regulation of cell cycle, interferes with DNA repair, induces genetic instability, transactivates FGF-2 and VEGF and promotes angiogenesis and tumor invasion. Simultaneously, overexpression of PTTG induces tumor cell senescence through the DNA damage pathway, making pituitary adenoma possessing the potential self-limiting ability. To elucidate the mechanism of PTTG in the regulation of pituitary adenomas, we focus on both the positive and negative function of PTTG and find out key factors interacted with PTTG in pituitary adenomas. Furthermore, we discuss other possible mechanisms correlate with PTTG in pituitary adenoma initiation and development and the potential value of PTTG in clinical treatment." @default.
- W2962676493 created "2019-07-30" @default.
- W2962676493 creator A5067302327 @default.
- W2962676493 creator A5078479753 @default.
- W2962676493 creator A5085357939 @default.
- W2962676493 date "2019-10-24" @default.
- W2962676493 modified "2023-10-18" @default.
- W2962676493 title "PTTG has a Dual Role of Promotion-Inhibition in the Development of Pituitary Adenomas" @default.
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