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- W2962697121 endingPage "109129" @default.
- W2962697121 startingPage "109129" @default.
- W2962697121 abstract "Maternally expressed gene 3 (MEG3) is a long non-coding RNA (lncRNA) located on chromosome 14q32.3. Direct sequencing experiments have shown monoallelic expression of this lncRNA. Several studies have shown down-regulation of this lncRNA in human cancers. In some cases, hypermethylation of the promoter region has been suggested as the underlying mechanism. Functional studies have shown that this lncRNA controls expression of several tumor suppressor genes and oncogenes among them are p53, RB, MYC and TGF-β. Through regulation of Wnt-β-catenin pathway, it also affects epithelial-mesenchymal transition. In vitro studies have demonstrated contribution of MEG3 in defining response to chemotherapeutic agents such as paclitaxel, cisplatin and oxaliplatin. Certain polymorphisms within MEG3 are implicated in cancer risk (rs7158663, rs4081134 and rs11160608) or therapeutic response of cancer patients (rs10132552). Taken together, this lncRNA is regarded as a putative cancer biomarker and treatment target. In the current review, several aspects of the participation of MEG3 in carcinogenesis are discussed." @default.
- W2962697121 created "2019-07-30" @default.
- W2962697121 creator A5036114929 @default.
- W2962697121 creator A5083975126 @default.
- W2962697121 date "2019-10-01" @default.
- W2962697121 modified "2023-10-14" @default.
- W2962697121 title "Maternally expressed gene 3 (MEG3): A tumor suppressor long non coding RNA" @default.
- W2962697121 cites W1191344064 @default.
- W2962697121 cites W1571858136 @default.
- W2962697121 cites W1793796070 @default.
- W2962697121 cites W1899418860 @default.
- W2962697121 cites W1910504474 @default.
- W2962697121 cites W1951364332 @default.
- W2962697121 cites W1983250724 @default.
- W2962697121 cites W1984324177 @default.
- W2962697121 cites W1989126702 @default.
- W2962697121 cites W2003544524 @default.
- W2962697121 cites W2010914889 @default.
- W2962697121 cites W2013719305 @default.
- W2962697121 cites W2023346582 @default.
- W2962697121 cites W2025647419 @default.
- W2962697121 cites W2035918394 @default.
- W2962697121 cites W2050114212 @default.
- W2962697121 cites W2083033504 @default.
- W2962697121 cites W2099176640 @default.
- W2962697121 cites W2104798171 @default.
- W2962697121 cites W2105926260 @default.
- W2962697121 cites W2108618113 @default.
- W2962697121 cites W2124433932 @default.
- W2962697121 cites W2147535627 @default.
- W2962697121 cites W2151721435 @default.
- W2962697121 cites W2167980095 @default.
- W2962697121 cites W2174891444 @default.
- W2962697121 cites W2174896178 @default.
- W2962697121 cites W2193151864 @default.
- W2962697121 cites W2211242716 @default.
- W2962697121 cites W2212385672 @default.
- W2962697121 cites W2264877802 @default.
- W2962697121 cites W2269151736 @default.
- W2962697121 cites W2274781441 @default.
- W2962697121 cites W2287061185 @default.
- W2962697121 cites W2290026752 @default.
- W2962697121 cites W2409650768 @default.
- W2962697121 cites W2464460497 @default.
- W2962697121 cites W2468594717 @default.
- W2962697121 cites W2489217812 @default.
- W2962697121 cites W2519528904 @default.
- W2962697121 cites W2536022581 @default.
- W2962697121 cites W2549578627 @default.
- W2962697121 cites W2552206015 @default.
- W2962697121 cites W2555885116 @default.
- W2962697121 cites W2570194029 @default.
- W2962697121 cites W2587685360 @default.
- W2962697121 cites W2587945849 @default.
- W2962697121 cites W2592488370 @default.
- W2962697121 cites W2592692681 @default.
- W2962697121 cites W2597695017 @default.
- W2962697121 cites W2605001769 @default.
- W2962697121 cites W2606188254 @default.
- W2962697121 cites W2606811296 @default.
- W2962697121 cites W2607089824 @default.
- W2962697121 cites W2617831789 @default.
- W2962697121 cites W2634697123 @default.
- W2962697121 cites W2654372693 @default.
- W2962697121 cites W2727984351 @default.
- W2962697121 cites W2728912755 @default.
- W2962697121 cites W2736168607 @default.
- W2962697121 cites W2739330347 @default.
- W2962697121 cites W2741319794 @default.
- W2962697121 cites W2743222220 @default.
- W2962697121 cites W2744974259 @default.
- W2962697121 cites W2748918144 @default.
- W2962697121 cites W2762059502 @default.
- W2962697121 cites W2765744146 @default.
- W2962697121 cites W2767148998 @default.
- W2962697121 cites W2770866548 @default.
- W2962697121 cites W2791956041 @default.
- W2962697121 cites W2794624672 @default.
- W2962697121 cites W2795199023 @default.
- W2962697121 cites W2796298526 @default.
- W2962697121 cites W2803918240 @default.
- W2962697121 cites W2808731276 @default.
- W2962697121 cites W2809059454 @default.
- W2962697121 cites W2883193223 @default.
- W2962697121 cites W2885672963 @default.
- W2962697121 cites W2886416438 @default.
- W2962697121 cites W2887842784 @default.
- W2962697121 cites W2888049139 @default.
- W2962697121 cites W2888572704 @default.
- W2962697121 cites W2889438018 @default.
- W2962697121 cites W2891165745 @default.
- W2962697121 cites W2894581393 @default.
- W2962697121 cites W2894814195 @default.
- W2962697121 cites W2897119059 @default.
- W2962697121 cites W2898736938 @default.
- W2962697121 cites W2900685091 @default.
- W2962697121 cites W2901274238 @default.
- W2962697121 cites W2904953089 @default.