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• W2962783505 abstract "Although optimal control theory has been used for the theoretical study of anti-cancerous drugs scheduling optimization, with the aim of reducing the primary tumor volume, the effect on metastases is often ignored. Here, we use a previously published model for metastatic development to define an optimal control problem at the scale of the entire organism of the patient. In silico study of the impact of different scheduling strategies for anti-angiogenic and cytotoxic agents (either in monotherapy or in combination) is performed to compare a low-dose, continuous, metronomic administration scheme with a more classical maximum tolerated dose schedule. Simulation results reveal differences between primary tumor reduction and control of metastases but overall suggest use of the metronomic protocol." @default.
• W2962783505 created "2019-07-30" @default.
• W2962783505 creator A5063987547 @default.
• W2962783505 creator A5082159954 @default.
• W2962783505 date "2013-10-01" @default.
• W2962783505 modified "2023-10-10" @default.
• W2962783505 title "Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers" @default.
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• W2962783505 doi "https://doi.org/10.1016/j.jtbi.2013.06.036" @default.
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• W2962783505 hasPublicationYear "2013" @default.
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