FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2962823090> ?p ?o ?g. }

• W2962823090 endingPage "1003" @default.
• W2962823090 startingPage "987" @default.
• W2962823090 abstract "Tissue engineering technology is a promising therapeutic strategy in peripheral nerve injury. Schwann cells (SCs) are deemed to be a vital component of cell-based nerve regeneration therapies. Many methods for producing SC-like cells derived from adipose-derived stromal cells (ADSCs) have been explored, but their phenotypic and functional characteristics remain unsatisfactory.We investigated whether human ADSCs can be induced to differentiate into mature and stable SC-like cells with the addition of insulin, progestero``ne and glucocorticoids. The phenotypic and functional characteristics of new differentiated ADSCs (modified SC-like cells) were evaluated by real-time quantitative polymerase chain reaction, enzyme-linked immunosorbent assay and immunocytochemistry in vitro. Cells loaded into collagen sponge biomaterials were implanted around transected sciatic nerves with a 10-mm gap in vivo. The axon regrowth and functional recovery of the regenerated nerves were assessed by immunohistochemistry and Walking footprint analysis.After differentiation induction, the modified SC-like cells showed significantly up-regulated levels of S100B and P0 and enhanced proliferative and migratory capacities. In addition, the modified SC-like cells showed increased secretion of neurotrophic factors, and their functional characteristics were maintained for more than 3 weeks after removing the induction reagents. The modified SC-like cells exhibited significantly enhanced axon regrowth, myelination and functional recovery after sciatic nerve injury.Overall, the results suggest that this modified induction method can induce human ADSCs to differentiate into cells with the molecular and functional properties of mature SCs and increase the promotion of peripheral nerve regeneration." @default.
• W2962823090 created "2019-07-30" @default.
• W2962823090 creator A5009001630 @default.
• W2962823090 creator A5012541451 @default.
• W2962823090 creator A5035724323 @default.
• W2962823090 creator A5036211071 @default.
• W2962823090 creator A5042192237 @default.
• W2962823090 creator A5042483754 @default.
• W2962823090 creator A5048379858 @default.
• W2962823090 creator A5051544202 @default.
• W2962823090 creator A5058363207 @default.
• W2962823090 creator A5060901457 @default.
• W2962823090 creator A5061814935 @default.
• W2962823090 creator A5083664918 @default.
• W2962823090 creator A5084621356 @default.
• W2962823090 date "2019-09-01" @default.
• W2962823090 modified "2023-10-15" @default.
• W2962823090 title "Differentiated human adipose-derived stromal cells exhibit the phenotypic and functional characteristics of mature Schwann cells through a modified approach" @default.
• W2962823090 cites W1062849974 @default.
• W2962823090 cites W1882005590 @default.
• W2962823090 cites W1958675029 @default.
• W2962823090 cites W1964814333 @default.
• W2962823090 cites W1969820383 @default.
• W2962823090 cites W1972738290 @default.
• W2962823090 cites W1986147205 @default.
• W2962823090 cites W1988580985 @default.
• W2962823090 cites W1989853502 @default.
• W2962823090 cites W1992687021 @default.
• W2962823090 cites W1994576954 @default.
• W2962823090 cites W2004020795 @default.
• W2962823090 cites W2004394057 @default.
• W2962823090 cites W2012062982 @default.
• W2962823090 cites W2016306246 @default.
• W2962823090 cites W2017450962 @default.
• W2962823090 cites W2028934778 @default.
• W2962823090 cites W2031523552 @default.
• W2962823090 cites W2038205842 @default.
• W2962823090 cites W2039653102 @default.
• W2962823090 cites W2043253582 @default.
• W2962823090 cites W2044959577 @default.
• W2962823090 cites W2047424436 @default.
• W2962823090 cites W2051476941 @default.
• W2962823090 cites W2056714530 @default.
• W2962823090 cites W2063000103 @default.
• W2962823090 cites W2087022458 @default.
• W2962823090 cites W2092950961 @default.
• W2962823090 cites W2093359589 @default.
• W2962823090 cites W2094540333 @default.
• W2962823090 cites W2099455244 @default.
• W2962823090 cites W2106615861 @default.
• W2962823090 cites W2107815958 @default.
• W2962823090 cites W2109262633 @default.
• W2962823090 cites W2110301830 @default.
• W2962823090 cites W2114677114 @default.
• W2962823090 cites W2114721953 @default.
• W2962823090 cites W2115789073 @default.
• W2962823090 cites W2116804949 @default.
• W2962823090 cites W2124508950 @default.
• W2962823090 cites W2126511115 @default.
• W2962823090 cites W2126974532 @default.
• W2962823090 cites W2131916287 @default.
• W2962823090 cites W2136507093 @default.
• W2962823090 cites W2141585831 @default.
• W2962823090 cites W2141957935 @default.
• W2962823090 cites W2145343118 @default.
• W2962823090 cites W2148173491 @default.
• W2962823090 cites W2160787125 @default.
• W2962823090 cites W2161805341 @default.
• W2962823090 cites W2199218610 @default.
• W2962823090 cites W2329296251 @default.
• W2962823090 cites W2418913553 @default.
• W2962823090 cites W2592259129 @default.
• W2962823090 cites W2752220223 @default.
• W2962823090 cites W2789930460 @default.
• W2962823090 cites W2799841453 @default.
• W2962823090 cites W2801685318 @default.
• W2962823090 cites W2804191761 @default.
• W2962823090 cites W2806231407 @default.
• W2962823090 cites W2887932752 @default.
• W2962823090 cites W31789700 @default.
• W2962823090 cites W4252202082 @default.
• W2962823090 doi "https://doi.org/10.1016/j.jcyt.2019.04.061" @default.
• W2962823090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31351800" @default.
• W2962823090 hasPublicationYear "2019" @default.
• W2962823090 type Work @default.
• W2962823090 sameAs 2962823090 @default.
• W2962823090 citedByCount "15" @default.
• W2962823090 countsByYear W29628230902020 @default.
• W2962823090 countsByYear W29628230902021 @default.
• W2962823090 countsByYear W29628230902022 @default.
• W2962823090 countsByYear W29628230902023 @default.
• W2962823090 crossrefType "journal-article" @default.
• W2962823090 hasAuthorship W2962823090A5009001630 @default.
• W2962823090 hasAuthorship W2962823090A5012541451 @default.
• W2962823090 hasAuthorship W2962823090A5035724323 @default.
• W2962823090 hasAuthorship W2962823090A5036211071 @default.
• W2962823090 hasAuthorship W2962823090A5042192237 @default.
• W2962823090 hasAuthorship W2962823090A5042483754 @default.

• next