FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2962838410> ?p ?o ?g. }

• W2962838410 endingPage "2639.e5" @default.
• W2962838410 startingPage "2625" @default.
• W2962838410 abstract "Centromeric nucleosomes are at the interface of the chromosome and the kinetochore that connects to spindle microtubules in mitosis. The core centromeric nucleosome complex (CCNC) harbors the histone H3 variant, CENP-A, and its binding proteins, CENP-C (through its central domain; CD) and CENP-N (through its N-terminal domain; NT). CENP-C can engage nucleosomes through two domains: the CD and the CENP-C motif (CM). CENP-CCD is part of the CCNC by virtue of its high specificity for CENP-A nucleosomes and ability to stabilize CENP-A at the centromere. CENP-CCM is thought to engage a neighboring nucleosome, either one containing conventional H3 or CENP-A, and a crystal structure of a nucleosome complex containing two copies of CENP-CCM was reported. Recent structures containing a single copy of CENP-NNT bound to the CENP-A nucleosome in the absence of CENP-C were reported. Here, we find that one copy of CENP-N is lost for every two copies of CENP-C on centromeric chromatin just prior to kinetochore formation. We present the structures of symmetric and asymmetric forms of the CCNC that vary in CENP-N stoichiometry. Our structures explain how the central domain of CENP-C achieves its high specificity for CENP-A nucleosomes and how CENP-C and CENP-N sandwich the histone H4 tail. The natural centromeric DNA path in our structures corresponds to symmetric surfaces for CCNC assembly, deviating from what is observed in prior structures using artificial sequences. At mitosis, we propose that CCNC asymmetry accommodates its asymmetric connections at the chromosome/kinetochore interface. VIDEO ABSTRACT." @default.
• W2962838410 created "2019-07-30" @default.
• W2962838410 creator A5004155478 @default.
• W2962838410 creator A5011704533 @default.
• W2962838410 creator A5020786212 @default.
• W2962838410 creator A5025300008 @default.
• W2962838410 creator A5031920166 @default.
• W2962838410 creator A5066408090 @default.
• W2962838410 creator A5068972788 @default.
• W2962838410 creator A5078916441 @default.
• W2962838410 creator A5081340005 @default.
• W2962838410 date "2019-08-01" @default.
• W2962838410 modified "2023-10-14" @default.
• W2962838410 title "Structure of the Human Core Centromeric Nucleosome Complex" @default.
• W2962838410 cites W1495816175 @default.
• W2962838410 cites W1917235046 @default.
• W2962838410 cites W1945772050 @default.
• W2962838410 cites W1970549330 @default.
• W2962838410 cites W1971651847 @default.
• W2962838410 cites W1983632279 @default.
• W2962838410 cites W1988997227 @default.
• W2962838410 cites W1991594869 @default.
• W2962838410 cites W2005019868 @default.
• W2962838410 cites W2012017673 @default.
• W2962838410 cites W2013711216 @default.
• W2962838410 cites W2014200281 @default.
• W2962838410 cites W2017914102 @default.
• W2962838410 cites W2018707048 @default.
• W2962838410 cites W2019842414 @default.
• W2962838410 cites W2023431649 @default.
• W2962838410 cites W2029873987 @default.
• W2962838410 cites W2032183039 @default.
• W2962838410 cites W2040109903 @default.
• W2962838410 cites W2061401851 @default.
• W2962838410 cites W2075763595 @default.
• W2962838410 cites W2076095878 @default.
• W2962838410 cites W2082001960 @default.
• W2962838410 cites W2104234755 @default.
• W2962838410 cites W2107501370 @default.
• W2962838410 cites W2109534255 @default.
• W2962838410 cites W2122956708 @default.
• W2962838410 cites W2124026197 @default.
• W2962838410 cites W2132629607 @default.
• W2962838410 cites W2141223744 @default.
• W2962838410 cites W2142161929 @default.
• W2962838410 cites W2144792857 @default.
• W2962838410 cites W2145579024 @default.
• W2962838410 cites W2146138912 @default.
• W2962838410 cites W2148430914 @default.
• W2962838410 cites W2151553287 @default.
• W2962838410 cites W2159234539 @default.
• W2962838410 cites W2162563461 @default.
• W2962838410 cites W2166056574 @default.
• W2962838410 cites W2167279371 @default.
• W2962838410 cites W2180229411 @default.
• W2962838410 cites W2208907061 @default.
• W2962838410 cites W2240680061 @default.
• W2962838410 cites W2287998160 @default.
• W2962838410 cites W2486677479 @default.
• W2962838410 cites W2507133578 @default.
• W2962838410 cites W2514292180 @default.
• W2962838410 cites W2548947017 @default.
• W2962838410 cites W2559865743 @default.
• W2962838410 cites W2582965622 @default.
• W2962838410 cites W2590824789 @default.
• W2962838410 cites W2593511418 @default.
• W2962838410 cites W2623038702 @default.
• W2962838410 cites W2734356283 @default.
• W2962838410 cites W2741012700 @default.
• W2962838410 cites W2776561065 @default.
• W2962838410 cites W2778507724 @default.
• W2962838410 cites W2786623728 @default.
• W2962838410 cites W2794729149 @default.
• W2962838410 cites W2802136660 @default.
• W2962838410 cites W2899760200 @default.
• W2962838410 cites W2913686253 @default.
• W2962838410 cites W2914595352 @default.
• W2962838410 cites W2945328347 @default.
• W2962838410 cites W2948322052 @default.
• W2962838410 cites W2950967305 @default.
• W2962838410 cites W2963890628 @default.
• W2962838410 cites W3000967366 @default.
• W2962838410 doi "https://doi.org/10.1016/j.cub.2019.06.062" @default.
• W2962838410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6702948" @default.
• W2962838410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31353180" @default.
• W2962838410 hasPublicationYear "2019" @default.
• W2962838410 type Work @default.
• W2962838410 sameAs 2962838410 @default.
• W2962838410 citedByCount "54" @default.
• W2962838410 countsByYear W29628384102019 @default.
• W2962838410 countsByYear W29628384102020 @default.
• W2962838410 countsByYear W29628384102021 @default.
• W2962838410 countsByYear W29628384102022 @default.
• W2962838410 countsByYear W29628384102023 @default.
• W2962838410 crossrefType "journal-article" @default.
• W2962838410 hasAuthorship W2962838410A5004155478 @default.
• W2962838410 hasAuthorship W2962838410A5011704533 @default.
• W2962838410 hasAuthorship W2962838410A5020786212 @default.

• next