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• W2962842826 abstract "Abstract The vacuole is the hydrolytic compartment of yeast cells and has a similar function as the lysosome of higher eukaryotes in detoxification and recycling of macromolecules. We analysed the contribution of single vacuolar enzymes to pexophagy and identified the phospholipase Atg15, the V-ATPase factor Vma2 and the serine-protease Prb1 along with the already known aspartyl-protease Pep4 (Proteinase A) to be required for this pathway. We also analysed the trafficking receptor Vps10, which is required for an efficient vacuolar targeting of the precursor form of Pep4. Here we demonstrate a novel context-dependent role of Vps10 in autophagy. We show that reduced maturation of Pep4 in a VPS10 -deletion strain affects the proteolytic activity of the vacuole depending on the type and amount of substrate. The VPS10 -deletion has no effect on the degradation of the cytosolic protein Pgk1 via bulk autophagy or on the degradation of ribosomes via ribophagy. In contrast, the degradation of an excess of peroxisomes via pexophagy as well as mitochondria via mitophagy was significantly hampered in a VPS10 -deletion strain and correlated with a decreased maturation level of Pep4. The results show that Vps10-mediated targeting of Pep4 limits the proteolytic capacity of the vacuole in a substrate-dependent manner." @default.
• W2962842826 created "2019-07-30" @default.
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• W2962842826 date "2019-07-22" @default.
• W2962842826 modified "2023-10-18" @default.
• W2962842826 title "Vps10-mediated targeting of Pep4 determines the activity of the vacuole in a substrate-dependent manner" @default.
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• W2962842826 doi "https://doi.org/10.1038/s41598-019-47184-7" @default.
• W2962842826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6646403" @default.
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• W2962842826 hasPublicationYear "2019" @default.
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