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• W2962978312 startingPage "3097" @default.
• W2962978312 abstract "Metalloproteinases-such as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs)-are involved in various diseases of the nervous system but also contribute to nervous system development, synaptic plasticity and neuroregeneration upon injury. MMPs and ADAMs proteolytically cleave many substrates including extracellular matrix components but also signaling molecules and receptors. During neuroinfectious disease with associated neuroinflammation, MMPs and ADAMs regulate blood-brain barrier breakdown, bacterial invasion, neutrophil infiltration and cytokine signaling. Specific and broad-spectrum inhibitors for MMPs and ADAMs have experimentally been shown to decrease neuroinflammation and brain damage in diseases with excessive neuroinflammation as a common denominator, such as pneumococcal meningitis and multiple sclerosis, thereby improving the disease outcome. Timing of metalloproteinase inhibition appears to be critical to effectively target the cascade of pathophysiological processes leading to brain damage without inhibiting the neuroregenerative effects of metalloproteinases. As the critical role of metalloproteinases in neuronal repair mechanisms and regeneration was only lately recognized, the original idea of chronic MMP inhibition needs to be conceptually revised. Recently accumulated research urges for a second chance of metalloproteinase inhibitors, which-when correctly applied and dosed-harbor the potential to improve the outcome of different neuroinflammatory diseases." @default.
• W2962978312 created "2019-07-30" @default.
• W2962978312 creator A5022896497 @default.
• W2962978312 creator A5025369887 @default.
• W2962978312 creator A5064977458 @default.
• W2962978312 creator A5076575343 @default.
• W2962978312 date "2019-06-06" @default.
• W2962978312 modified "2023-10-15" @default.
• W2962978312 title "MMPs and ADAMs in neurological infectious diseases and multiple sclerosis" @default.
• W2962978312 cites W1490135869 @default.
• W2962978312 cites W1504544942 @default.
• W2962978312 cites W1513704400 @default.
• W2962978312 cites W1538666979 @default.
• W2962978312 cites W1553036924 @default.
• W2962978312 cites W1571690868 @default.
• W2962978312 cites W1581404300 @default.
• W2962978312 cites W1596996340 @default.
• W2962978312 cites W1730313527 @default.
• W2962978312 cites W1756801153 @default.
• W2962978312 cites W1846885120 @default.
• W2962978312 cites W1907716756 @default.
• W2962978312 cites W1940973248 @default.
• W2962978312 cites W1955736456 @default.
• W2962978312 cites W1963904679 @default.
• W2962978312 cites W1964369359 @default.
• W2962978312 cites W1965672526 @default.
• W2962978312 cites W1968168664 @default.
• W2962978312 cites W1968558772 @default.
• W2962978312 cites W1968754528 @default.
• W2962978312 cites W1969414295 @default.
• W2962978312 cites W1971029155 @default.
• W2962978312 cites W1973833307 @default.
• W2962978312 cites W1975019144 @default.
• W2962978312 cites W1975663198 @default.
• W2962978312 cites W1976944470 @default.
• W2962978312 cites W1977200209 @default.
• W2962978312 cites W1979347099 @default.
• W2962978312 cites W1981290690 @default.
• W2962978312 cites W1981978112 @default.
• W2962978312 cites W1982669828 @default.
• W2962978312 cites W1983463114 @default.
• W2962978312 cites W1987177757 @default.
• W2962978312 cites W1987825791 @default.
• W2962978312 cites W1987897015 @default.
• W2962978312 cites W1988284222 @default.
• W2962978312 cites W1991506612 @default.
• W2962978312 cites W1993101179 @default.
• W2962978312 cites W1993373387 @default.
• W2962978312 cites W1994349595 @default.
• W2962978312 cites W1994623742 @default.
• W2962978312 cites W1996353122 @default.
• W2962978312 cites W1996944708 @default.
• W2962978312 cites W1997358669 @default.
• W2962978312 cites W1998557118 @default.
• W2962978312 cites W1998975199 @default.
• W2962978312 cites W1999004700 @default.
• W2962978312 cites W2001262287 @default.
• W2962978312 cites W2001314174 @default.
• W2962978312 cites W2001979726 @default.
• W2962978312 cites W2005491839 @default.
• W2962978312 cites W2005675003 @default.
• W2962978312 cites W2005993855 @default.
• W2962978312 cites W2009021998 @default.
• W2962978312 cites W2009263722 @default.
• W2962978312 cites W2010817955 @default.
• W2962978312 cites W2011029038 @default.
• W2962978312 cites W2012162957 @default.
• W2962978312 cites W2013377378 @default.
• W2962978312 cites W2014971932 @default.
• W2962978312 cites W2015627246 @default.
• W2962978312 cites W2016504217 @default.
• W2962978312 cites W2017172546 @default.
• W2962978312 cites W2019007505 @default.
• W2962978312 cites W2021769399 @default.
• W2962978312 cites W2023250693 @default.
• W2962978312 cites W2024061399 @default.
• W2962978312 cites W2025064470 @default.
• W2962978312 cites W2025258577 @default.
• W2962978312 cites W2025764040 @default.
• W2962978312 cites W2025847142 @default.
• W2962978312 cites W2029325168 @default.
• W2962978312 cites W2030104330 @default.
• W2962978312 cites W2030276061 @default.
• W2962978312 cites W2030776545 @default.
• W2962978312 cites W2031609743 @default.
• W2962978312 cites W2032743208 @default.
• W2962978312 cites W2032851354 @default.
• W2962978312 cites W2033233627 @default.
• W2962978312 cites W2033341544 @default.
• W2962978312 cites W2033671240 @default.
• W2962978312 cites W2033828724 @default.
• W2962978312 cites W2033966441 @default.
• W2962978312 cites W2034804703 @default.
• W2962978312 cites W2035779766 @default.
• W2962978312 cites W2035800592 @default.
• W2962978312 cites W2036209224 @default.
• W2962978312 cites W2036842448 @default.
• W2962978312 cites W2038353560 @default.

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